Preliminary results in anterior cervical discectomy and fusion with the uncovertebral joint fusion cage in a goat model.
Preliminary results in anterior cervical discectomy and fusion with the uncovertebral joint fusion cage in a goat model.
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DOI：
10.1186/s12891-021-04412-4
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发表时间：
2021-07-17
影响因子：
2.3
通讯作者：
Hong Y
中科院分区：
文献类型：
--
作者：
Shen YW;Yang Y;Liu H;Wu TK;Ma LT;Chen L;Hu LY;Ding C;Rong X;Wang BY;Meng Y;Hong Y
目的：初步评价裸露椎体关节融合器在山羊颈椎椎间融合模型中的安全性和有效性。将24只健康成年山羊随机分为两组：A组植入无椎体关节融合笼并植入局部自体移植物；B组植入无椎体融合笼并植入局部自体移植物。前瞻性评价24周后处死评价。采用x线、CT和micro-CT扫描以及未钙化骨组织学分析评估融合情况。A组12周融合率为75.0% (9/12)，B组为41.7%（5/12）。A组24周融合率为83.3% (10/12)，B组为58.3%（7/12）。A组12周和24周融合率评分均显著高于B组（P < 0.05）。显微ct扫描及未钙化骨组织分析显示，双侧无椎关节处可见明显的新骨形成。A组骨体积分数（BV/ TV）（23.59±4.43%）显著高于B组（16.16±4.21%），差异有统计学意义（P < 0.05）。本研究的初步结果表明，非椎体关节融合器可以有效地实现早期骨形成和融合，而不会增加严重并发症。
To preliminarily evaluate the safety and efficacy of the uncovertebral joint fusion cage in a goat model of cervical spine interbody fusion. Twenty-four healthy adult goats were randomly assigned to one of the two following groups: Group A, goats were implanted with an uncovertebral joint fusion cage combined with a local autograft and Group B, goats were implanted with a non-profile cage filled with a local autograft. The goats were prospectively evaluated for 24 weeks and then were sacrificed for evaluation. X-rays, CT and micro-CT scanning, and undecalcified bone histological analysis were used for the evaluation of fusion. 75.0% (9/12) of the goats in Group A were evaluated as having fusion at 12 weeks, compared to 41.7% (5/12) in Group B. 83.3% (10/12) of the goats in Group A were evaluated as having fusion at 24 weeks compared to 58.3% (7/12) in Group B. The fusion grading scores in Group A were significantly higher than that in Group B both at 12 weeks and 24 weeks (P < 0.05). Micro-CT scanning and undecalcified bone histological analysis showed that new bone formation can be obviously found in the bilateral uncovertebral joint. The bone volume fraction (BV/ TV) in Group A (23.59 ± 4.43%) was significantly higher than Group B (16.16 ± 4.21%), with P < 0.05. Preliminary results of this study demonstrated that uncovertebral joint fusion cage is effective for achieving early bone formation and fusion without increase of serious complications.
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影响因子：
3
作者：
Buchowski, Jacob M.;Liu, Gabriel;Riew, K. Daniel
通讯作者：
Riew, K. Daniel
影响因子：
3
作者：
Neo, Masashi;Fujibayashi, Shunsuke;Nakamura, Takashi
通讯作者：
Nakamura, Takashi
影响因子：
6.4
作者：
Kolar, Paula;Schmidt-Bleek, Katharina;Duda, Georg N.
通讯作者：
Duda, Georg N.
DOI：
10.1016/j.jmbbm.2019.07.015
发表时间：
2019-11-01
影响因子：
3.9
作者：
Meeson, Richard;Moazen, Mehran;Blunn, Gordon
通讯作者：
Blunn, Gordon
影响因子：
--
作者：
Goffin, J;Geusens, E;van Loon, J
通讯作者：
van Loon, J