A guide to plasma membrane solute carrier proteins.
A guide to plasma membrane solute carrier proteins.
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DOI：
10.1111/febs.15531
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Superti-Furga G
中科院分区：
文献类型：
--
作者：
Pizzagalli MD;Bensimon A;Superti-Furga G
本文旨在介绍溶质载体蛋白（SLC）转运蛋白超家族及其在人体细胞中的作用。SLC超家族目前包括65个家族的458个转运蛋白，这些转运蛋白在细胞膜上携带多种物质。虽然这个超家族的成员遍布细胞器，但本文主要关注在质膜上表达的转运蛋白。在细胞表面，SLC蛋白可以被视为细胞环境的守门人，动态响应不同的代谢状态。由于代谢改变是癌症的标志之一，我们也简要回顾了表面SLC蛋白通过调节代谢和环境条件在癌症发生和进展中的作用。在这篇“SLC蛋白指南”中，我们专注于转运蛋白-被称为溶质载体(SLC) -在质膜上表达。我们的目的是提供一个有用的调查代谢物和离子是如何在细胞外和细胞内的环境之间运输。由于代谢改变是癌症的标志之一，我们也简要回顾了表面SLCs在癌症发生和进展中的作用。
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily of transporter proteins and their roles in human cells. The SLC superfamily currently includes 458 transport proteins in 65 families that carry a wide variety of substances across cellular membranes. While members of this superfamily are found throughout cellular organelles, this review focuses on transporters expressed at the plasma membrane. At the cell surface, SLC proteins may be viewed as gatekeepers of the cellular milieu, dynamically responding to different metabolic states. With altered metabolism being one of the hallmarks of cancer, we also briefly review the roles that surface SLC proteins play in the development and progression of cancer through their influence on regulating metabolism and environmental conditions. In this ‘A Guide to SLC proteins’, we focus on transporter proteins—known as solute carriers (SLCs)—expressed on the plasma membrane. We aim to provide a useful survey of how metabolites and ions are transported between the extracellular and intracellular milieus. With altered metabolism being one of the hallmarks of cancer, we also briefly review roles that surface SLCs play in the development and progression of cancer.
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影响因子：
4.8
作者：
Andrikopoulos, Petros;Baba, Akemichi;Eccles, Suzanne A.
通讯作者：
Eccles, Suzanne A.
影响因子：
8
作者：
Ames, Samantha;Andring, Jacob T.;Becker, Holger M.
通讯作者：
Becker, Holger M.
影响因子：
16.6
作者：
Alguel Y;Amillis S;Leung J;Lambrinidis G;Capaldi S;Scull NJ;Craven G;Iwata S;Armstrong A;Mikros E;Diallinas G;Cameron AD;Byrne B
通讯作者：
Byrne B
影响因子：
14.9
作者：
UniProt Consortium
通讯作者：
UniProt Consortium
影响因子：
5.5
作者：
Abuladze, N;Azimov, R;Kurtz, I
通讯作者：
Kurtz, I