Autophagy and inflammation.
Autophagy and inflammation.
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DOI：
10.1186/s40169-017-0154-5
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发表时间：
2017-12
影响因子：
10.6
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Qian M;Fang X;Wang X
自噬是一种动态平衡机制，通过溶酶体降解途径处理受损的细胞器、变性的蛋白质以及入侵的病原体。近年来，越来越多的证据表明其在先天免疫和获得性免疫中的作用，从而影响炎症性疾病的发病机制。自噬机制的检测有助于在生理和病理生理过程中测量自噬。自噬通过影响巨噬细胞、中性粒细胞和淋巴细胞等炎性细胞的发育、稳态和生存，影响多种细胞因子的转录、加工和分泌，并受细胞因子的调节，在炎症反应中发挥重要作用。近年来，在感染性疾病、克罗恩病、囊性纤维化、肺高压、慢性阻塞性肺疾病等多种炎症性疾病的发病机制中，对自噬依赖的机制进行了研究。这些研究表明，自噬的调节可能导致对与炎症相关的疾病的治疗干预。在这里，我们重点介绍最近在研究自噬在炎症和炎症性疾病中的作用方面的进展。
Autophagy is a homeostatic mechanism involved in the disposal of damaged organelles, denatured proteins as well as invaded pathogens through a lysosomal degradation pathway. Recently, increasing evidences have demonstrated its role in both innate and adaptive immunity, and thereby influence the pathogenesis of inflammatory diseases. The detection of autophagy machinery facilitated the measurement of autophagy during physiological and pathophysiological processes. Autophagy plays critical roles in inflammation through influencing the development, homeostasis and survival of inflammatory cells, including macrophages, neutrophils and lymphocytes; effecting the transcription, processing and secretion of a number of cytokines, as well as being regulated by cytokines. Recently, autophagy-dependent mechanisms have been studied in the pathogenesis of several inflammatory diseases, including infectious diseases, Crohn’s disease, cystic fibrosis, pulmonary hypertension, chronic obstructive pulmonary diseases and so on. These studies suggested that modulation of autophagy might lead to therapeutic interventions for diseases associated with inflammation. Here we highlight recent advances in investigating the roles of autophagy in inflammation as well as inflammatory diseases.
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影响因子：
4.6
作者：
Agrawal V;Jaiswal MK;Mallers T;Katara GK;Gilman-Sachs A;Beaman KD;Hirsch E
通讯作者：
Hirsch E
影响因子：
3.3
作者：
Ding, Yan;Choi, Maly E.
通讯作者：
Choi, Maly E.
影响因子：
5.6
作者：
Chen, Dexiu;Liu, Junshan;Wang, Ming
通讯作者：
Wang, Ming
影响因子：
6.1
作者：
Denardin, Cristiane C.;Martins, Leo A. M.;Costa Rodrigues Guma, Fatima
通讯作者：
Costa Rodrigues Guma, Fatima
影响因子：
6
作者：
El Kebir D;Filep JG
通讯作者：
Filep JG