Regulation of autophagy by TGF-β: emerging role in kidney fibrosis.
Regulation of autophagy by TGF-β: emerging role in kidney fibrosis.
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DOI：
10.1016/j.semnephrol.2013.11.009
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发表时间：
2014-01
影响因子：
3.3
通讯作者：
Choi, Maly E.
中科院分区：
文献类型：
--
作者：
Ding, Yan;Choi, Maly E.
自噬是一种高度保守的细胞在应激条件下生存的同源平衡机制，并且被广泛认为是许多生物过程和疾病的重要途径。在进行性肾脏疾病中，纤维化是终末期肾衰竭的常见途径。转化生长因子-β1（Transforming growth factor-β 1，TGF-β1）是一种多效性细胞因子，已被确定为肾纤维化的中枢介质。最近出现的来自培养物和实验动物模型中的肾细胞研究的证据表明，TGF-β1调节自噬，并且自噬调节与肾纤维化相关的正常和疾病状况的许多关键方面，如肾小管间质纤维化、肾小球硬化和糖尿病肾病。本文就自噬过程、TGF-β1对自噬的调控及其在进行性肾纤维化和损伤反应中的作用作一综述。了解这一过程的细胞和分子基础对于确定肾纤维化潜在的新诊断和治疗靶点至关重要。
Autophagy is a highly conserved homoeostatic mechanism for cell survival under conditions of stress, and is widely implicated as an important pathway in many biological processes and diseases. In progressive kidney diseases, fibrosis represents the common pathway to end-stage kidney failure. Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that has been established as a central mediator of kidney fibrosis. Recently emerging body of evidence from studies in renal cells in culture and experimental animal models suggests that TGF-β1 regulates autophagy and that autophagy regulates many critical aspects of normal and disease conditions associated with kidney fibrosis, such as tubulointerstitial fibrosis, glomerulosclerosis, and diabetic nephropathy. Here, we review the recent advances exploring the process of autophagy, its regulation by TGF-β1, and implication in the pathogenesis of progressive kidney fibrosis and injury responses. Understanding the cellular and molecular bases of this process is crucial for identifying potential new diagnostic and therapeutic targets of kidney fibrosis.
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影响因子：
3.3
作者：
Choi, Mary E.;Ding, Yan;Kim, Sung Il
通讯作者：
Kim, Sung Il
影响因子：
3.7
作者：
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3
作者：
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DOI：
10.1152/ajprenal.2001.280.3.f495
发表时间：
2001-03-01
影响因子：
4.2
作者：
Chin, BY;Mohsenin, A;Choi, ME
通讯作者：
Choi, ME
影响因子：
3.3
作者：
Gewin L;Zent R
通讯作者：
Zent R