Nicotine exposure beginning in adolescence enhances the acquisition of methamphetamine self-administration, but not methamphetamine-primed reinstatement in male rats.
Nicotine exposure beginning in adolescence enhances the acquisition of methamphetamine self-administration, but not methamphetamine-primed reinstatement in male rats.
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DOI：
10.1016/j.drugalcdep.2014.06.029
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发表时间：
2014-09-01
影响因子：
4.2
通讯作者：
Crawford, Cynthia A.
中科院分区：
文献类型：
--
作者：
Pipkin, Joseph A.;Kaplan, Graham J.;Plant, Christopher P.;Eaton, Shannon E.;Gil, Susan M.;Zayala, Arturo R.;Crawford, Cynthia A.
尼古丁通常在青春期被滥用，被认为是滥用其他药物的“门户”[例如，甲基苯丙胺（METH）]。早期尼古丁暴露与后期METH使用之间的关系是复杂的，因为大多数青少年吸烟者继续使用香烟到成年。因此，本调查研究了青少年和成人尼古丁暴露对METH自我管理的个体和综合贡献。43只雄性大鼠从出生后第35-50天（PD）开始接受生理盐水或尼古丁（0.16或0.64 mg/kg，SC）预处理。PD 51时，受试者被分为以下组：0.16/0.16、0.16/SAL、0.64/0.64和0.64/SAL。然后训练大鼠按FR 1和FR 3强化计划分别用METH（0.05 mg/kg）杠杆按压7天和7天。在获得训练后，大鼠经历14天的消退，然后测试MET诱导的引发恢复（1.0 mg/kg，IP）。数据显示，接受低剂量尼古丁（0.16/0.16）连续注射的大鼠在FR 1和FR 3时间表上获得了比对照组更多的METH输注（SAL/SAL）。此外，仅在青春期接受低剂量尼古丁（0.16/SAL）的FR 3方案大鼠的METH摄入量高于对照组（SAL/SAL）。有趣的是，高剂量的尼古丁暴露对METH摄入量没有影响，尼古丁剂量也没有改变METH寻求行为。在青春期低剂量暴露于尼古丁增强了METH的强化作用，而更重的暴露对METH的摄入没有影响。
Nicotine is commonly abused in adolescence and is believed to be a “gateway” to other drugs of abuse [e.g., methamphetamine (METH)]. The relationship between early nicotine exposure and later METH use is complicated because the majority of juvenile smokers continue to use cigarettes into adulthood. Thus, the present investigation examined the individual and combined contribution of adolescent and adult nicotine exposure on METH self administration. Forty-three male rats were pretreated with saline or nicotine (0.16 or 0.64 mg/kg, SC) from postnatal day (PD) 35–50. On PD 51, subjects were split into the following groups: 0.16/0.16, 0.16/SAL, 0.64/0.64, and 0.64/SAL. Rats were then trained to lever press for METH (0.05 mg/kg) for seven days on an FR1 and seven days on an FR3 reinforcement schedule. After acquisition training, rats underwent 14 days of extinction and were then tested for METH-induced primed reinstatement (1.0 mg/kg, IP). Data showed that rats receiving continuous injections of the low dose of nicotine (0.16/0.16) obtained more METH infusions versus the control group (SAL/SAL) on an FR1 and FR3 schedule. In addition, rats on the FR3 schedule that received a low dose of nicotine during the adolescent period only (0.16/SAL) had more METH intake than the control group (SAL/SAL). Interestingly, the high dose of nicotine exposure had no effect on METH intake and neither nicotine dose altered METH seeking behavior. Low dose exposure to nicotine during adolescence enhances the reinforcing effects of METH, while heavier exposure has no effect on METH intake.
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影响因子：
4.2
作者：
Neugebauer, N. M.;Harrod, S. B.;Bardo, M. T.
通讯作者：
Bardo, M. T.
影响因子：
3.8
作者：
Brensilver, Matthew;Heinzerling, Keith G.;Shoptaw, Steven J.
通讯作者：
Shoptaw, Steven J.
影响因子：
3.7
作者：
Nakagawa T;Suzuki Y;Nagayasu K;Kitaichi M;Shirakawa H;Kaneko S
通讯作者：
Kaneko S
影响因子：
3.4
作者：
Kitamura, O;Wee, S;Pulvirenti, L
通讯作者：
Pulvirenti, L
影响因子：
3.3
作者：
Mattsson, A;Pernold, K;Olson, L
通讯作者：
Olson, L