Distribution of Genes Encoding Nucleoid-Associated Protein Homologs in Plasmids
Distribution of Genes Encoding Nucleoid-Associated Protein Homologs in Plasmids
复制标题
编码类核相关蛋白同源物的基因在质粒中的分布
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
H. Nojiri
中科院分区：
文献类型：
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作者：
T. Takeda;C. Yun;M. Shintani;H. Yamane;H. Nojiri
细菌类核相关蛋白（NAPs）形成核蛋白复合物并影响基因的表达。最近的研究表明，一些质粒携带编码NAP同源物的基因，NAP同源物在质粒和宿主染色体之间的转录调控网络中发挥重要作用。在这项研究中，我们确定了已知的NAP Fis，H-NS，HU，IHF和Lrp以及新发现的NAP MvaT和NdpA在革兰氏阴性菌中发现的全测序的1382个质粒中的分布。NAP分布和质粒特征（大小，G+C含量和推定的可转移性）之间的比较也进行了。我们发现较大的质粒经常有NAP基因同源物。具有H-NS基因同源物的质粒G+C含量较少。应该指出的是，与NAP基因同源物的质粒也进行松弛酶基因参与接合转移的质粒比那些没有NAP基因同源物，这意味着质粒编码的NAP同源物积极有助于可传播的质粒。
Bacterial nucleoid-associated proteins (NAPs) form nucleoprotein complexes and influence the expression of genes. Recent studies have shown that some plasmids carry genes encoding NAP homologs, which play important roles in transcriptional regulation networks between plasmids and host chromosomes. In this study, we determined the distributions of the well-known NAPs Fis, H-NS, HU, IHF, and Lrp and the newly found NAPs MvaT and NdpA among the whole-sequenced 1382 plasmids found in Gram-negative bacteria. Comparisons between NAP distributions and plasmid features (size, G+C content, and putative transferability) were also performed. We found that larger plasmids frequently have NAP gene homologs. Plasmids with H-NS gene homologs had less G+C content. It should be noted that plasmids with the NAP gene homolog also carried the relaxase gene involved in the conjugative transfer of plasmids more frequently than did those without the NAP gene homolog, implying that plasmid-encoded NAP homologs positively contribute to transmissible plasmids.
影响因子：
2.8
作者：
Bradley, Meranda D.;Beach, Michael B.;Osuna, Robert
通讯作者：
Osuna, Robert
影响因子：
14.9
作者：
Sherburne, CK;Lawley, TD;Taylor, DE
通讯作者：
Taylor, DE