Extracellular vesicles: Critical players during cell migration.
Extracellular vesicles: Critical players during cell migration.
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DOI：
10.1016/j.devcel.2021.03.020
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发表时间：
2021-07-12
影响因子：
11.8
通讯作者：
Weaver AM
中科院分区：
文献类型：
--
作者：
Sung BH;Parent CA;Weaver AM
细胞迁移对于多细胞生物体的发育和维持至关重要，有助于胚胎发生、伤口愈合、免疫反应和其他关键过程。它还参与许多疾病的发病机制，包括免疫缺陷疾病和癌症转移。最近，细胞外囊泡（EV）已被证明在细胞迁移中发挥重要作用。在这里，我们回顾了最近的研究，描述了电动汽车在细胞运动的多个方面的功能，包括定向传感，细胞粘附，细胞外基质（ECM）降解，和领导者跟随者的行为。我们还讨论了EV在发育和疾病过程中迁移的作用，以及成像工具在研究EV在细胞迁移中的作用方面的实用性。细胞迁移对于多细胞生物的发育和维持是必不可少的，并且也有助于疾病的发病机制。Sung等人回顾了最近的研究，这些研究描述了细胞外囊泡在细胞运动的各个方面的功能，包括定向传感、细胞粘附、细胞外基质（ECM）降解和领导者-跟随者行为。
Cell migration is essential for the development and maintenance of multicellular organisms, contributing to embryogenesis, wound healing, immune response, and other critical processes. It is also involved in the pathogenesis of many diseases, including immune deficiency disorders and cancer metastasis. Recently, extracellular vesicles (EVs) have been shown to play important roles in cell migration. Here, we review recent studies describing the functions of EVs in multiple aspects of cell motility, including directional sensing, cell adhesion, extracellular matrix (ECM) degradation, and leader-follower behavior. We also discuss the role of EVs in migration during development and disease and the utility of imaging tools for studying the role of EVs in cell migration. Cell migration is essential for the development and maintenance of multicellular organisms, and also contributes to the pathogenesis of disease. Sung et al. review recent studies describing the functions of extracellular vesicles in various aspects of cell motility, including directional sensing, cell adhesion, extracellular matrix (ECM) degradation, and leader-follower behavior.
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影响因子：
16.6
作者：
Desrochers LM;Bordeleau F;Reinhart-King CA;Cerione RA;Antonyak MA
通讯作者：
Antonyak MA
影响因子：
16.6
作者：
Clancy, James W.;Sedgwick, Alanna;Rosse, Carine;Muralidharan-Chari, Vandhana;Raposo, Graca;Method, Michael;Chavrier, Philippe;D'Souza-Schorey, Crislyn
通讯作者：
D'Souza-Schorey, Crislyn
影响因子：
30.5
作者：
通讯作者：
--
DOI：
10.18632/aging.101355
发表时间：
2017-12-28
期刊：
Aging
影响因子：
--
作者：
Bhome R;Goh RW;Bullock MD;Pillar N;Thirdborough SM;Mellone M;Mirnezami R;Galea D;Veselkov K;Gu Q;Underwood TJ;Primrose JN;De Wever O;Shomron N;Sayan AE;Mirnezami AH
通讯作者：
Mirnezami AH
影响因子：
15.1
作者：
Danzer KM;Kranich LR;Ruf WP;Cagsal-Getkin O;Winslow AR;Zhu L;Vanderburg CR;McLean PJ
通讯作者：
McLean PJ