TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans.
TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans.
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DOI：
10.1155/2015/124357
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发表时间：
2015
影响因子：
--
通讯作者：
Wätjen W
中科院分区：
文献类型：
--
作者：
Büchter C;Zhao L;Havermann S;Honnen S;Fritz G;Proksch P;Wätjen W
2,3,5,4'-四羟基芪-2-O-β-D-葡萄糖苷 (TSG) 是从何首乌中分离出来的，何首乌是一种传统上用作抗衰老药物的植物。我们分析了 TSG 与白藜芦醇相比对模式生物秀丽隐杆线虫的衰老相关影响。 TSG 在无细胞测定和线虫实验中都发挥了高抗氧化能力。与白藜芦醇相比，其抗氧化能力甚至更高。可能由于其抗氧化作用，TSG 治疗降低了胡桃醌介导的抗氧化酶 SOD-3 的诱导；胡桃醌对GST-4的诱导略有减弱。 TSG 比白藜芦醇更能显着提高线虫对致命热应激的抵抗力（50μM TSG 使平均存活率提高 22.2%）。与该化合物一起孵育后，老化色素脂褐质的水平降低。 TSG 使秀丽隐杆线虫的平均、中位和最大成年寿命分别延长 23.5%、29.4% 和 7.2%，与白藜芦醇的效果相当。 TSG 介导的寿命延长在 DAF-16 功能丧失突变株中并未被消除，这表明这种与衰老相关的转录因子不参与 TSG 的作用。我们的数据表明，TSG 具有强大的抗氧化能力，增强线虫的抗应激能力，并延长线虫的寿命。
2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) was isolated from Polygonum multiflorum, a plant which is traditionally used as an anti-ageing drug. We have analysed ageing-related effects of TSG in the model organism C. elegans in comparison to resveratrol. TSG exerted a high antioxidative capacity both in a cell-free assay and in the nematode. The antioxidative capacity was even higher compared to resveratrol. Presumably due to its antioxidative effects, treatment with TSG decreased the juglone-mediated induction of the antioxidative enzyme SOD-3; the induction of the GST-4 by juglone was diminished slightly. TSG increased the resistance of C. elegans against lethal thermal stress more prominently than resveratrol (50 μM TSG increased mean survival by 22.2%). The level of the ageing pigment lipofuscin was decreased after incubation with the compound. TSG prolongs the mean, median, and maximum adult life span of C. elegans by 23.5%, 29.4%, and 7.2%, respectively, comparable to the effects of resveratrol. TSG-mediated extension of life span was not abolished in a DAF-16 loss-of-function mutant strain showing that this ageing-related transcription factor is not involved in the effects of TSG. Our data show that TSG possesses a potent antioxidative capacity, enhances the stress resistance, and increases the life span of the nematode C. elegans.
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影响因子：
2.4
作者：
Jiang, Bei;Guo, Ling;Gao, Hai-Qing
通讯作者：
Gao, Hai-Qing
DOI：
10.1073/pnas.0610068104
发表时间：
2007-04-24
影响因子：
11.1
作者：
Dasgupta, Biplab;Milbrandt, Jeffrey
通讯作者：
Milbrandt, Jeffrey
影响因子：
5.4
作者：
Kim, Ha Neui;Kim, Yu Ri;Choi, Byung Tae
通讯作者：
Choi, Byung Tae
影响因子：
9.3
作者：
Kampkoetter, A.;Pielarski, T.;Kahl, R.
通讯作者：
Kahl, R.
影响因子：
7.4
作者：
Cadenas, E;Davies, KJA
通讯作者：
Davies, KJA