Primary cilia in the postnatal brain: Subcellular compartments for organizing neuromodulatory signaling.
Primary cilia in the postnatal brain: Subcellular compartments for organizing neuromodulatory signaling.
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DOI：
10.1016/j.conb.2022.102533
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发表时间：
2022-06
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
初级纤毛在早期大脑发育中具有很好的特征，在胚胎阶段传递神经发生和大脑形成的关键信号。对纤毛介导的信号传导对产后脑功能的作用了解较少。在成年神经元中已经发现了几种结合神经肽和脑内源性神经递质的纤毛定位受体，但通过这些纤毛定位受体传递信号的功能意义在很大程度上尚未被探索。人类纤毛病通常表现为神经发育异常和认知缺陷。有趣的是，最近的研究还将几种神经精神疾病和神经退行性疾病与纤毛功能障碍联系起来。本文综述了纤毛信号可能动态调节出生后神经元生理和连接的最新证据，并强调了纤毛、神经元回路、神经元存活和神经系统疾病之间的可能联系。
Primary cilia have well characterized roles in early brain development, relaying signals critical for neurogenesis and brain formation during embryonic stages. Less understood are the contributions of cilia-mediated signaling to postnatal brain function. Several cilia-localized receptors that bind neuropeptides and neurotransmitters endogenous to the brain have been identified in adult neurons, but the functional significance of signaling through these cilia-localized receptors is largely unexplored. Ciliopathic disorders in humans often manifest with neurodevelopmental abnormalities and cognitive deficits. Intriguingly, recent research has also linked several neuropsychiatric disorders and neurodegenerative diseases to ciliary dysfunction. This review summarizes recent evidence suggesting that cilia signaling may dynamically regulate postnatal neuronal physiology and connectivity, and highlights possible links among cilia, neuronal circuitry, neuron survival, and neurological disorders.
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