The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration.
The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration.
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DOI：
10.3389/fendo.2022.1081185
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发表时间：
2022
影响因子：
5.2
通讯作者：
Hao, Dingjun
中科院分区：
文献类型：
--
作者：
Jiang, Chao;Chen, Zhe;Wang, Xiaohui;Zhang, Yongyuan;Guo, Xinyu;Xu, Zhengwei;Yang, Hao;Hao, Dingjun
下腰痛(LBP)是最常见的肌肉骨骼症状之一，严重影响患者的生活质量。大多数人可能会在一生中患上腰痛，给家庭和社会带来巨大的经济负担。根据以往的一系列研究，腰椎间盘退行性变(IDD)被认为是导致LBP的主要因素。此外，非编码RNA(NcRNAs)，主要包括微小RNAs(MiRNAs)、长非编码RNAs(LncRNAs)和环状RNAs(CircRNAs)，可以调节多种细胞过程，在IDD的发生发展中起着关键作用。然而，ncRNAs在IDD过程中的潜在作用机制仍然完全不清楚。因此，考虑将ncRNAs作为IDD的潜在治疗靶点是具有挑战性的。本文综述了近年来有关IDD中ncRNAs的研究进展和发现。NcRNAs主要通过调节髓核(NP)细胞的凋亡、细胞外基质(ECM)的代谢和炎症反应参与IDD的发病过程。MiRNAs/lncRNAs/CircRNAs在IDD发病中的作用是串扰的，类似于网络，可以相互调节；NcRNAs已经被尝试用来对抗退变过程，并有望在未来成为一种有效的生物治疗策略。因此，该综述系统地总结了IDD的主要发病机制，并阐明了ncRNAs在IDD中的治疗潜力。
Low back pain (LBP) is one of the most common musculoskeletal symptoms and severely affects patient quality of life. The majority of people may suffer from LBP during their life-span, which leading to huge economic burdens to family and society. According to the series of the previous studies, intervertebral disc degeneration (IDD) is considered as the major contributor resulting in LBP. Furthermore, non-coding RNAs (ncRNAs), mainly including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), can regulate diverse cellular processes, which have been found to play pivotal roles in the development of IDD. However, the potential mechanisms of action for ncRNAs in the processes of IDD are still completely unrevealed. Therefore, it is challenging to consider ncRNAs to be used as the potential therapeutic targets for IDD. In this paper, we reviewed the current research progress and findings on ncRNAs in IDD: i). ncRNAs mainly participate in the process of IDD through regulating apoptosis of nucleus pulposus (NP) cells, metabolism of extracellular matrix (ECM) and inflammatory response; ii). the roles of miRNAs/lncRNAs/circRNAs are cross-talk in IDD development, which is similar to the network and can modulate each other; iii). ncRNAs have been attempted to combat the degenerative processes and may be promising as an efficient bio-therapeutic strategy in the future. Hence, this review systematically summarizes the principal pathomechanisms of IDD and shed light on the therapeutic potentials of ncRNAs in IDD.
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影响因子：
8.5
作者：
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通讯作者：
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