Molecular imaging probes for diagnosis and therapy evaluation of breast cancer.
Molecular imaging probes for diagnosis and therapy evaluation of breast cancer.
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DOI：
10.1155/2013/230487
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发表时间：
2013
影响因子：
7.6
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Meng Q;Li Z
乳腺癌是妇女癌症死亡的一个主要原因，早期发现和准确评估治疗反应可以改善临床结果。分子成像，包括PET、SPECT、MRI和光学模式，提供了检测体内生物过程和分子事件的非侵入性手段。在药物开发的临床前和临床阶段，分子成像有可能增强我们对乳腺癌生物学和药物作用效应的理解。这导致了许多分子成像探针在乳腺癌的关键过程的鉴定。激素受体、生长因子受体和血管生成因子，如ER、PR、HER2、VEGFR等已被作为乳腺癌的检测、分期和治疗效果监测的影像学靶点。受体成像探针通常由附着在信号组件上的靶向片段组成，例如可以使用专用仪器检测到的放射性核素。综述了分子成像探针在乳腺癌诊断和治疗评价中的应用现状，并对分子成像在临床前和临床中的应用前景进行了展望。
Breast cancer is a major cause of cancer death in women where early detection and accurate assessment of therapy response can improve clinical outcomes. Molecular imaging, which includes PET, SPECT, MRI, and optical modalities, provides noninvasive means of detecting biological processes and molecular events in vivo. Molecular imaging has the potential to enhance our understanding of breast cancer biology and effects of drug action during both preclinical and clinical phases of drug development. This has led to the identification of many molecular imaging probes for key processes in breast cancer. Hormone receptors, growth factor receptor, and angiogenic factors, such as ER, PR, HER2, and VEGFR, have been adopted as imaging targets to detect and stage the breast cancer and to monitor the treatment efficacy. Receptor imaging probes are usually composed of targeting moiety attached to a signaling component such as a radionuclide that can be detected using dedicated instruments. Current molecular imaging probes involved in breast cancer diagnosis and therapy evaluation are reviewed, and future of molecular imaging for the preclinical and clinical is explained.
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影响因子：
3.1
作者：
Chen, XY;Liu, S;Conti, PS
通讯作者：
Conti, PS
影响因子：
9.3
作者：
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通讯作者：
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影响因子：
46.9
作者：
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通讯作者：
Grötzinger, C
影响因子：
5.6
作者：
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通讯作者：
Abrahmsen, Lars
影响因子：
1.3
作者：
Axelsson, Rimma;Bach-Gansmo, Tore;McParland, Brian J.
通讯作者：
McParland, Brian J.