Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
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DOI：
10.1371/journal.pone.0014732
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发表时间：
2011-02-25
期刊：
影响因子：
3.7
通讯作者：
Ramchandran R
中科院分区：
文献类型：
--
作者：
Chun CZ;Remadevi I;Schupp MO;Samant GV;Pramanik K;Wilkinson GA;Ramchandran R
Vasculogenesis, the de novo formation of blood vessels from precursor cells is critical for a developing embryo. However, the signals and events that dictate the formation of primary axial vessels remain poorly understood. In this study, we use ets-related protein-1 (etsrp), which is essential for vascular development, to analyze the early stages of vasculogenesis in zebrafish. We found etsrp + cells of the head, trunk and tail follow distinct developmental sequences. Using a combination of genetic, molecular and chemical approaches, we demonstrate that fli + etsrp + hemato-vascular progenitors (FEVPs) are proliferating at the lateral plate mesoderm (LPM). The Shh-VEGF-Notch-Hey2 signaling pathway controls the proliferation process, and experimental modulation of single components of this pathway alters etsrp + cell numbers at the LPM. This study for the first time defines factors controlling proliferation, and cell numbers of pre-migratory FEVPs in zebrafish.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0604203103
发表时间：
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