Screening Binary Systems of Chelating Agents Combined with Carbon or Silica Gel Adsorbents: The Development of a Cost-Effective Method to Remove Palladium from Pharmaceutical Intermediates and APIs
Screening Binary Systems of Chelating Agents Combined with Carbon or Silica Gel Adsorbents: The Development of a Cost-Effective Method to Remove Palladium from Pharmaceutical Intermediates and APIs
复制标题
筛选螯合剂与碳或硅胶吸附剂结合的二元系统：开发一种经济有效的方法来去除药物中间体和 API 中的钯
DOI：
10.1021/op2001657
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发表时间：
2011
影响因子：
3.4
通讯作者：
Cui Jian
中科院分区：
文献类型：
--
作者：
Lijun Wang;Leopold N. Green;Zhen Li;J. Dunn;X. Bu;C. Welch;Chunyu Li;Tiebang Wang;Q. Tu;E. Bekos;D. Richardson;J. Eckert;Cui Jian
钯催化剂在药物中间体和活性药物成分（API）合成中的使用越来越多，这使得对去除所产生的金属污染物的成本效益方法的需求不断增加。开发了一种简单的二元钯清除系统，使用螯合剂与活性炭或硅胶吸附剂组合。成功的钯去除后，证明了几个反应流处理污染的解决方案与二元系统，然后过滤。提出该二元体系以有效地提供原位生成的金属清除剂，但通常成本比相应的商业固体负载的清除剂低得多。
The increasing use of palladium catalysts in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs) has created the rising need for cost-effective ways to remove the resulting metal contaminants. A simple binary palladium scavenging system was developed using a chelating agent in combination with either activated carbon or silica gel adsorbents. Successful palladium removal was demonstrated on several reaction streams after treating contaminated solutions with the binary system followed by filtration. The binary system is proposed to effectively provide an in situ generated metal scavenger, but typically costs much less than corresponding commercial solid-supported scavengers.
影响因子：
15
作者：
Huang, XH;Anderson, KW;Buchwald, SL
通讯作者：
Buchwald, SL