Comparative analysis of lifestyle factors, screening test use, and clinicopathologic features in association with survival among Asian Americans with colorectal cancer.
Comparative analysis of lifestyle factors, screening test use, and clinicopathologic features in association with survival among Asian Americans with colorectal cancer.
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生活方式因素、筛查测试的使用和临床病理特征与亚裔美国人结直肠癌生存相关的比较分析
DOI：
10.1038/bjc.2013.97
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发表时间：
2013-04-16
影响因子：
8.8
通讯作者：
Li, X.
中科院分区：
文献类型：
--
作者：
Yi, M.;Xu, J.;Liu, P.;Chang, G. J.;Du, X. L.;Hu, C-y;Song, Y.;He, J.;Ren, Y.;Wei, Y.;Yang, J.;Hunt, K. K.;Li, X.
在美国，结直肠癌(CRC)的诊断和疾病特异性生存率(DSS)在不同种族之间存在差异。然而，很少有研究评估亚洲亚群之间的差异。监测、流行病学和最终结果(SEER)数据库用于在1988至2008年间识别侵袭性结直肠癌患者。比较不同亚型之间临床病理特征和DSS发生率的差异。加州健康访谈调查被用来检查结直肠癌的危险因素和筛查模式。这项研究包括359名 患者，其中8.4%为亚洲人。所有亚裔患者确诊时的年龄(中位数：68岁)均比非西班牙裔白人(NHW)患者(中位数：72岁)年轻。除夏威夷人外，大多数亚洲亚组的DSS比NHW患者更好，尽管亚洲亚组的疾病比NHW患者更晚期。印度/巴基斯坦患者的5年DSS高于其他亚洲亚组。亚洲人群的肥胖比例(50.2%)低于nhw人群(59.8%)。越南男性和韩国女性接受结直肠癌筛查的比例最低。在每个种族组中，肿瘤分期进展与较差的DSS高度相关。在NHW、菲律宾人和中国人中，肿瘤级别高与较差的DSS相关。在除夏威夷人和越南人以外的大多数种族群体中，确诊时年龄较大的人与较差的DSS有关。亚裔与非华裔儿童之间，以及不同亚裔亚群之间存在差异。癌症临床病理特征、患者的行为习惯、生活方式和筛查模式的差异可能解释了不同种族之间观察到的结直肠癌存活率的一些差异。
Colorectal cancer (CRC) diagnoses and disease-specific survival (DSS) vary between ethnic groups in the United States. However, few studies have assessed differences among Asian subgroups. The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients with invasive CRC between 1988 and 2008. Differences in clinicopathologic features, and DSS rates were compared among Asian subgroups. The California Health Interview Survey was used to examine risk factors and screening patterns for CRC. The study included 359 374 patients with 8.4% Asian. Patients in all Asian subgroups were younger (median: 68 years) at diagnosis than non-Hispanic white (NHW) patients (median: 72 years). Most Asian subgroups, except Hawaiians, had better DSS than NHW patients although Asian subgroups had more advanced disease than NHW. Indian/Pakistani patients had a higher 5-year DSS than other Asian subgroups. Obesity proportions were lower in Asian subgroups (<50.2%) than in NHW (59.8%). Vietnamese men and Korean women had the lowest proportions of CRC screening. Advance tumour stages were highly associated with worse DSS in each ethnicity group. High tumour grades were associated with worse DSS in NHW, Filipino, and Chinese. Older age at diagnosis was associated with worse DSS in most ethnicity groups except Hawaiian and Vietnamese. Disparities exist between Asians and NHW with CRC, and among various Asian subgroups. Differences in cancer clinicopathologic features, patients' behavioural habits, lifestyle, and screening patterns may explain some differences in CRC survival observed among ethnic groups.
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影响因子：
2.3
作者：
Giddings, Brenda Hofer;Kwong, Sandy L.;Snipes, Kurt P.
通讯作者：
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