Susceptibility of North American ducks and gulls to H5N1 highly pathogenic avian influenza viruses.
Susceptibility of North American ducks and gulls to H5N1 highly pathogenic avian influenza viruses.
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DOI：
10.3201/eid1211.060652
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发表时间：
2006-11
影响因子：
11.8
通讯作者：
Swayne DE
中科院分区：
文献类型：
--
作者：
Brown JD;Stallknecht DE;Beck JR;Suarez DL;Swayne DE
在感染H5 N1高致病性禽流感病毒的北美鸭和海鸥之间，存在着与种属相关的临床反应、病毒脱落持续时间和程度的差异。自2002年以来，H5 N1高致病性禽流感（HPAI）病毒与欧亚大陆许多野生鸟类物种的死亡有关。我们评估了5种北美鸭和笑鸥（Larus atricilla）经鼻内攻击2种亚洲H5 N1高致病性禽流感病毒后的临床反应以及病毒脱落的程度和持续时间。鸡在10 - 16周龄时攻毒，与病毒流行和秋季迁徙的时间高峰一致。所有物种都受到感染，但只有林鸭（Aix sponsa）和笑鸥表现出疾病或死亡。口咽拭子中的病毒滴度高于泄殖腔拭子。病毒脱落的持续时间（1-10天）随着临床疾病的严重程度而增加。血凝抑制试验（HI）和琼脂凝胶沉淀素试验（AGP）均能检测到存活的林鸭和笑鸥的免疫后抗体，其中HI试验的敏感性高于AGP
Species-related differences in clinical response and duration and extent of viral shedding exist between North American ducks and gulls infected with H5N1 HPAI viruses. Since 2002, H5N1 highly pathogenic avian influenza (HPAI) viruses have been associated with deaths in numerous wild avian species throughout Eurasia. We assessed the clinical response and extent and duration of viral shedding in 5 species of North American ducks and laughing gulls (Larus atricilla) after intranasal challenge with 2 Asian H5N1 HPAI viruses. Birds were challenged at ≈10 to 16 weeks of age, consistent with temporal peaks in virus prevalence and fall migration. All species were infected, but only wood ducks (Aix sponsa) and laughing gulls exhibited illness or died. Viral titers were higher in oropharyngeal swabs than in cloacal swabs. Duration of viral shedding (1–10 days) increased with severity of clinical disease. Both the hemagglutination-inhibition (HI) and agar gel precipitin (AGP) tests were able to detect postinoculation antibodies in surviving wood ducks and laughing gulls; the HI test was more sensitive than the AGP in the remaining 4 species
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影响因子：
3.7
作者：
Webster RG;Yakhno M;Hinshaw VS;Bean WJ;Murti KG
通讯作者：
Murti KG
影响因子：
2.4
作者：
Perkins, LEL;Swayne, DE
通讯作者：
Swayne, DE
DOI：
10.20506/rst.14.3.880
发表时间：
1995-09-01
期刊：
REVUE SCIENTIFIQUE ET TECHNIQUE DE L OFFICE INTERNATIONAL DES EPIZOOTIES
影响因子：
--
作者：
BARBEITO, MS;ABRAHAM, G;THOMPSON, LH
通讯作者：
THOMPSON, LH
影响因子：
5.4
作者：
Sturm-Ramirez, KM;Hulse-Post, DJ;Webster, RG
通讯作者：
Webster, RG
影响因子：
1.4
作者：
STALLKNECHT, DE;SHANE, SM;ZWANK, PJ
通讯作者：
ZWANK, PJ