Intestinal influenza: replication and characterization of influenza viruses in ducks.
Intestinal influenza: replication and characterization of influenza viruses in ducks.
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DOI：
10.1016/0042-6822(78)90247-7
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发表时间：
1978-03
期刊：
影响因子：
3.7
通讯作者：
Murti KG
中科院分区：
文献类型：
--
作者：
Webster RG;Yakhno M;Hinshaw VS;Bean WJ;Murti KG
从自然感染的野鸭泄殖腔中分离出的甲型流感病毒在野鸭和家鸭的肺部以及肠道内壁细胞中复制。尽管砂囊的pH值较低，鸭流感病毒仍通过消化道到达肠道，并在粪便中浓度很高。病毒在粪便中的感染性在 4° 下至少保留 30 天，在 20° 下至少保留 7 天。从粪便中分离出的从未在胚蛋中传播的一株肠鸭流感病毒（Hav7 Neg2）的形态大致为球形，大小和形状相当均匀。然而，研究的另一种鸭流感病毒株（Hav3 Nav6）主要是丝状的，这表明流感病毒在其自然宿主中的形态因毒株而异。在鸡胚中传代后，每个菌株都保留了粪便中的形态特征。与鸭流感病毒相反，HON1、H3N2和Hswl N1亚型的代表性人类流感病毒仅在鸭的上呼吸道中复制。鸭流感病毒对低 pH 值比人类病毒株更稳定，在 0° 的非氯化河水中可保持感染性 30 天以上，在 22° 时可保持 4 天。鸭子对人类和禽类流感病毒株感染的易感性以及通过供水传播到动物物种的可能性表明，鸭子可能在流感病毒生态中发挥重要作用。考虑“肠流感”病毒疫苗的可能性。
Influenza A viruses isolated from the cloaca of naturally infected feral ducks replicate in the lungs and in the cells lining the intestinal tract of feral and domestic ducks. Despite the low pH of the gizzard, the duck influenza viruses reach the intestines via the digestive tract and are found in high concentration in the feces. The viruses retain infectivity in fecal material for at least 30 days at 4° and for 7 days at 20°. The morphology of one strain of intestinal duck influenza virus (Hav7 Neg2) that had never been passed in embryonated eggs and was isolated from the feces was roughly spherical and fairly uniform in size and shape. However, another strain of duck influenza virus studied (Hav3 Nav6) was predominantly filamentous, suggesting that the morphology of influenza viruses in their natural hosts varies from strain to strain. After passage in the chick embryo each strain retained the morphological characteristics found in the feces. In contrast to duck influenza viruses, representative human influenza viruses of the HON1, H3N2, and Hswl Nl subtypes replicate only in the upper respiratory tract of ducks. The duck influenza viruses are more stable to low pH than human strains and retain infectivity for over 30 days in nonchlorinated river water at 0° and for 4 days at 22°. The susceptibility of ducks to infection with human and avian strains of influenza virus and the possibility of transmission to animal species through the water supply suggests that ducks may be important in the ecology of influenza viruses. The possibility of “intestinal influenza” virus vaccines is considered.
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影响因子：
3.7
作者：
LAVER, WG;WEBSTER, RG
通讯作者：
WEBSTER, RG
DOI：
10.1099/00221287-19-1-23
发表时间：
1958-01-01
期刊：
JOURNAL OF GENERAL MICROBIOLOGY
影响因子：
--
作者：
ADA, GL;PERRY, BT;ABBOT, A
通讯作者：
ABBOT, A
影响因子：
2.8
作者：
CHAGNON, A;GILKER, JC;BOUDREAULT, A
通讯作者：
BOUDREAULT, A
影响因子：
15.3
作者：
CHOPPIN, PW;MURPHY, JS;TAMM, I
通讯作者：
TAMM, I
影响因子：
3.8
作者：
WEBSTER, RG;MORITA, M;TUMOVA, B
通讯作者：
TUMOVA, B