MicroRNAs as Regulators of Cancer Cell Energy Metabolism.
MicroRNAs as Regulators of Cancer Cell Energy Metabolism.
复制标题
DOI：
10.3390/jpm12081329
复制
发表时间：
2022-08-18
影响因子：
--
通讯作者：
Shanmughapriya, Santhanam
中科院分区：
文献类型：
--
作者：
Suriya Muthukumaran, Natarajaseenivasan;Velusamy, Prema;Akino Mercy, Charles Solomon;Langford, Dianne;Natarajaseenivasan, Kalimuthusamy;Shanmughapriya, Santhanam
为了适应肿瘤环境或逃避化疗，癌细胞迅速重新编程其代谢。癌细胞的标志性生化表型是代谢重编程向有氧糖酵解的转变。人们认为，这种向糖酵解的代谢转变本身就足以满足癌细胞增殖和生存所需的更高能量和代谢需求。然而，最近的研究表明，癌细胞依靠谷氨酰胺、脂质和线粒体代谢来获取能量。癌基因和清除途径控制着许多这些代谢变化，一些代谢和致瘤途径是由microRNA （mirna）转录后调节的。在细胞中直接或间接负责能量产生的基因或负或正受到mirna的调节。因此，一些mirna通过调节癌细胞中发生的代谢变化发挥致癌作用。此外，mirna可以调节线粒体钙储存和能量代谢，从而促进癌细胞存活、细胞生长和转移。在电子传递链（ETC）中，miRNAs增强了凋亡诱导因子（AIF）和细胞色素c的活性，这些凋亡蛋白被定向到ETC而不是凋亡途径。本文将重点介绍miRNAs如何调节癌细胞代谢和线粒体钙输入/输出途径的酶、信号通路和转录因子。本综述还将重点关注癌细胞的代谢重编程，以促进生存、增殖、生长和转移，并强调mirna在癌症治疗中的治疗潜力。
To adapt to the tumor environment or to escape chemotherapy, cancer cells rapidly reprogram their metabolism. The hallmark biochemical phenotype of cancer cells is the shift in metabolic reprogramming towards aerobic glycolysis. It was thought that this metabolic shift to glycolysis alone was sufficient for cancer cells to meet their heightened energy and metabolic demands for proliferation and survival. Recent studies, however, show that cancer cells rely on glutamine, lipid, and mitochondrial metabolism for energy. Oncogenes and scavenging pathways control many of these metabolic changes, and several metabolic and tumorigenic pathways are post-transcriptionally regulated by microRNA (miRNAs). Genes that are directly or indirectly responsible for energy production in cells are either negatively or positively regulated by miRNAs. Therefore, some miRNAs play an oncogenic role by regulating the metabolic shift that occurs in cancer cells. Additionally, miRNAs can regulate mitochondrial calcium stores and energy metabolism, thus promoting cancer cell survival, cell growth, and metastasis. In the electron transport chain (ETC), miRNAs enhance the activity of apoptosis-inducing factor (AIF) and cytochrome c, and these apoptosome proteins are directed towards the ETC rather than to the apoptotic pathway. This review will highlight how miRNAs regulate the enzymes, signaling pathways, and transcription factors of cancer cell metabolism and mitochondrial calcium import/export pathways. The review will also focus on the metabolic reprogramming of cancer cells to promote survival, proliferation, growth, and metastasis with an emphasis on the therapeutic potential of miRNAs for cancer treatment.
登录
查看更多内容
影响因子：
--
作者：
Bhanot H;Weisberg EL;Reddy MM;Nonami A;Neuberg D;Stone RM;Podar K;Salgia R;Griffin JD;Sattler M
通讯作者：
Sattler M
MicroRNA-129-5p 通过靶向胃癌细胞中的葡萄糖转运蛋白 SLC2A3 来调节糖酵解和细胞增殖
影响因子：
5.6
作者：
Chen D;Wang H;Chen J;Li Z;Li S;Hu Z;Huang S;Zhao Y;He X
通讯作者：
He X
影响因子：
11.2
作者：
Ahmad A;Aboukameel A;Kong D;Wang Z;Sethi S;Chen W;Sarkar FH;Raz A
通讯作者：
Raz A
MiR-181a 通过 IDH1 调节脂质代谢
影响因子：
4.6
作者：
Chu B;Wu T;Miao L;Mei Y;Wu M
通讯作者：
Wu M
DOI：
10.1073/pnas.0800121105
发表时间：
2008-04-01
影响因子：
11.1
作者：
Calin, George A.;Cimmino, Amelia;Croce, Carlo M.
通讯作者：
Croce, Carlo M.