Recent advances in stealth coating of nanoparticle drug delivery systems.

Recent advances in stealth coating of nanoparticle drug delivery systems.
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DOI:
10.1002/wnan.1157
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发表时间:
2012-03
影响因子:
8.6
通讯作者:
Yeo, Yoon
Yeo, Yoon
中科院分区:
医学2区
文献类型:
--
作者:
Amoozgar, Zohreh;Yeo, Yoon

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Modifying surfaces of nanoparticles (NPs) with polyethylene glycol (PEG), the so called PEGylation, is the most commonly used method for reducing premature clearance of NPs from the circulation. However, several reports point out that PEGylation may negatively influence the performance of NPs as a drug carrier. Alternative surface modification strategies, including substitute polymers, conditional removal of PEG, and biomimetic surface modification, may provide solutions for the limitations of PEG.
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