Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy.
Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy.
复制标题
图像引导质子治疗后，前列腺癌患者的性功能和血清睾丸激素水平的变化。
DOI：
10.1093/jrr/rrab002
复制
发表时间：
2021-05-12
影响因子：
2
通讯作者：
Shibamoto Y
中科院分区：
文献类型：
--
作者：
Hattori Y;Iwata H;Nakajima K;Nomura K;Hayashi K;Toshito T;Hashimoto S;Umemoto Y;Mizoe JE;Ogino H;Shibamoto Y
由于影像引导质子治疗（IGPT）后的性功能和睾酮水平尚未得到详细研究，我们对IGPT前后的变化进行了前瞻性评估。在2013年2月至2014年9月期间接受IGPT治疗（联合或不联合雄激素阻断（CAB）治疗）的患者中，对同意参与研究且在IGPT后随访>3年的患者进行了评估。在IGPT前后定期测量血清睾酮水平以及前列腺特异性抗原（PSA）水平。评估了勃起硬度评分（EHS）以及扩展前列腺癌指数综合评分（EPIC）中的性领域总结、功能子量表和困扰子量表。有38例低风险、46例中风险以及43例高风险或极高风险患者（美国国立综合癌症网络（NCCN）分类）。尽管低风险患者的血清睾酮水平在IGPT后没有下降，但观察到EPIC的平均EHS和性领域总结评分有所降低。在中风险、高风险和极高风险患者中，IGPT后CAB终止后睾酮和PSA水平均升高，平均EHS升高。性领域总结评分逐渐升高，但未超过最小重要差异。在中风险患者中，功能子量表在IGPT后12个月从4.4升高到14.8（P < 0.05），并在60个月后达到平台期。本研究结果提示了IGPT的潜力，有必要进一步开展前瞻性研究以直接比较IGPT与其他治疗方式。
Since sexual function and testosterone levels after image-guided proton therapy (IGPT) have not yet been examined in detail, we prospectively evaluated changes before and after IGPT. Among patients treated with IGPT with or without combined androgen blockade (CAB) therapy between February 2013 and September 2014, patients who agreed to participate in the study and were followed up for >3 years after IGPT were evaluated. Serum testosterone levels were regularly measured together with prostate-specific antigen (PSA) levels before and after IGPT. The Erection Hardness Score (EHS) and the sexual domain summary, function subscale and bother subscale of the sexual domain in the Expanded Prostate Cancer Index Composite (EPIC) were assessed. There were 38 low-risk, 46 intermediate-risk and 43 high- or very-high-risk patients (NCCN classification). Although serum testosterone levels in low-risk patients did not decrease after IGPT, reductions were observed in the average EHS and the sexual domain summary score of the EPIC. In intermediate-, high- and very-high-risk patients, testosterone and PSA levels both increased following the termination of CAB after IGPT, and the average EHS increased. The sexual domain summary score gradually increased, but not above minimally important differences. In intermediate-risk patients, the function subscale increased from 4.4 to 14.8 (P < 0.05) 12 months after IGPT and reached a plateau after 60 months. The results of the present study would suggest the potential of IGPT, and further prospective studies to directly compare IGPT with other modalities are warranted.
登录
查看更多内容
影响因子：
5.7
作者：
Levin-Epstein, Rebecca;Cook, Ryan R.;Kishan, Amar U.
通讯作者：
Kishan, Amar U.
影响因子：
2.3
作者：
Nichols RC;Hu C;Bahary JP;Zeitzer KL;Souhami L;Leibenhaut MH;Rotman M;Gore EM;Balogh AG;McGowan D;Michalski J;Raben A;Rudoler S;Jones CU;Sandler H
通讯作者：
Sandler H
对医疗统计信息的自由使用的易于使用的软件“ EZR”的调查。
影响因子：
4.8
作者：
Kanda Y
通讯作者：
Kanda Y
DOI：
10.1016/j.ijrobp.2013.11.007
发表时间：
2014-03-01
影响因子：
7
作者：
Mendenhall, Nancy P.;Hoppe, Bradford S.;Henderson, Randal H.
通讯作者：
Henderson, Randal H.
影响因子：
2.3
作者：
Miyake, Hideaki;Miyazaki, Akira;Fujisawa, Masato
通讯作者：
Fujisawa, Masato