Advances in understanding cancer-associated neurogenesis and its implications on the neuroimmune axis in cancer.
Advances in understanding cancer-associated neurogenesis and its implications on the neuroimmune axis in cancer.
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DOI：
10.1016/j.pharmthera.2022.108199
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发表时间：
2022-11
影响因子：
13.5
通讯作者：
Amit, Moran
中科院分区：
文献类型：
--
作者：
Yaman, Ismail;Cobanoglu, Didem Agac;Xie, Tongxin;Ye, Yi;Amit, Moran
关键词：
神经和免疫介质通过多种机制相互作用，在机体内稳态中起着关键作用。神经在肿瘤微环境中的扩散增加了肿瘤细胞增殖和疾病进展，这与患者预后不良相关。交感神经和副交感神经对癌症调节的影响正在研究中。最近的研究结果表明，有可能开发针对肿瘤微环境及其组分（如免疫细胞、神经递质和细胞外囊泡）的治疗策略。因此，检查和理解与交感神经系统和副交感神经系统、神经递质、癌症源性介质及其在肿瘤微环境中与免疫系统的相互作用相关的机制和途径，可能会导致新的癌症治疗方法的开发。这篇综述讨论了神经细胞、免疫细胞和癌细胞相互之间调节神经发生、癌症进展和传播的作用。
Nerves and immunologic mediators play pivotal roles in body homeostasis by interacting with each other through diverse mechanisms. The spread of nerves in the tumor microenvironment increases tumor cell proliferation and disease progression, and this correlates with poor patient outcomes. The effects of sympathetic and parasympathetic nerves on cancer regulation are being investigated. Recent findings demonstrate the possibility of developing therapeutic strategies that target the tumor microenvironment and its components such as immune cells, neurotransmitters, and extracellular vesicles. Therefore, examining and understanding the mechanisms and pathways associated with the sympathetic and parasympathetic nervous systems, neurotransmitters, cancer-derived mediators and their interactions with the immune system in the tumor microenvironment may lead to the development of new cancer treatments. This review discusses the effects of nerve cells, immune cells, and cancer cells have on each other that regulate neurogenesis, cancer progression, and dissemination.
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DOI：
10.1002/pros.23454
发表时间：
2018-03
期刊：
The Prostate
影响因子：
--
作者：
Coarfa C;Florentin D;Putluri N;Ding Y;Au J;He D;Ragheb A;Frolov A;Michailidis G;Lee M;Kadmon D;Miles B;Smith C;Ittmann M;Rowley D;Sreekumar A;Creighton CJ;Ayala G
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影响因子：
16.6
作者：
通讯作者：
--
DOI：
10.1073/pnas.0911515107
发表时间：
2010-03-23
影响因子：
11.1
作者：
Cole, Steven W.;Arevalo, Jesusa M. G.;Seeman, Teresa E.
通讯作者：
Seeman, Teresa E.
影响因子：
29.4
作者：
Ceyhan, Gueralp O.;Bergmann, Frank;Friess, Helmut
通讯作者：
Friess, Helmut
影响因子：
4.3
作者：
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通讯作者：
Vere CC