Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System.
Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System.
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DOI：
10.1016/j.cmet.2017.05.008
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发表时间：
2017-07-05
期刊：
影响因子：
29
通讯作者：
Ghosh S
中科院分区：
文献类型：
--
作者：
Postler TS;Ghosh S
人类的胃肠道由一种多样化的、高度互惠的微生物菌群组成，这就是众所周知的微生物群。微生物组的破坏已被证明与宿主的严重病理有关，包括代谢性疾病、癌症和炎症性肠病。情绪和行为也容易受到肠道微生物区系变化的影响。微生物组的共生效应的一个特别明显的例子是免疫系统，其细胞的正常发育和行为严重依赖于一系列不同的微生物代谢物。这包括由细菌从饮食成分中产生的代谢物；由宿主产生并由肠道细菌进行生化修饰的代谢物；以及由肠道微生物从头合成的代谢物。在这篇综述中，我们强调了肠道微生物组在人类代谢性和炎症性疾病中的作用，并特别关注控制肠道免疫轴的分子机制。
The human gastrointestinal tract is populated by a diverse, highly mutualistic microbial flora, which is known as the microbiome. Disruptions to the microbiome have been shown to be associated with severe pathologies of the host including metabolic disease, cancer and inflammatory bowel disease. Mood and behavior are also susceptible to alterations in the gut microbiota. A particularly striking example of the symbiotic effects of the microbiome is the immune system, whose cells depend critically on a diverse array of microbial metabolites for normal development and behavior. This includes metabolites that are produced by bacteria from dietary components; metabolites that are produced by the host and biochemically modified by gut bacteria; and metabolites that are synthesized de novo by gut microbes. In this review, we highlight the role of the intestinal microbiome in human metabolic and inflammatory diseases and focus in particular on the molecular mechanisms that govern the gut-immune axis.
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影响因子：
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通讯作者：
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