Commensal bacteria at the interface of host metabolism and the immune system.
Commensal bacteria at the interface of host metabolism and the immune system.
复制标题
宿主代谢和免疫系统界面处的共生细菌。
作者：
哺乳动物的胃肠道是消化和营养吸收的场所，拥有来自所有三个生命领域的数万亿有益微生物。特别是共生细菌，是食物消化的关键参与者，负责提取和合成维持哺乳动物健康所必需的营养物质和其他代谢物。许多这些营养素和代谢产物来源于肠道细菌已牵连在免疫系统的发育，稳态和功能，这表明肠道细菌可能会影响宿主免疫通过营养和代谢依赖性机制。在这里，我们回顾了目前的知识，肠道细菌如何调节生产和生物利用度的免疫调节，饮食依赖性的营养物质和代谢产物，并讨论这些肠道细菌衍生的产品可能会调节哺乳动物免疫系统的发展和功能。
The mammalian gastrointestinal tract, the site of digestion and nutrient absorption, harbors trillions of beneficial commensal microbes from all three domains of life. Commensal bacteria, in particular, are key participants in the digestion of food, and are responsible for the extraction and synthesis of nutrients and other metabolites that are essential for the maintenance of mammalian health. Many of these nutrients and metabolites derived from commensal bacteria have been implicated in the development, homeostasis and function of the immune system, suggesting that commensal bacteria may influence host immunity via nutrient- and metabolite-dependent mechanisms. Here we review the current knowledge of how commensal bacteria regulate the production and bioavailability of immunomodulatory, diet-dependent nutrients and metabolites and discuss how these commensal bacteria-derived products may regulate the development and function of the mammalian immune system.
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影响因子：
3.7
作者：
Cipriani S;Mencarelli A;Chini MG;Distrutti E;Renga B;Bifulco G;Baldelli F;Donini A;Fiorucci S
通讯作者：
Fiorucci S
DOI：
10.1152/ajpendo.00229.2010
发表时间：
2011-01-01
影响因子：
5.1
作者：
Bjursell, Mikael;Admyre, Therese;Bohlooly-Y, Mohammad
通讯作者：
Bohlooly-Y, Mohammad
影响因子：
4.8
作者：
Brown, AJ;Goldsworthy, SM;Dowell, SJ
通讯作者：
Dowell, SJ
影响因子：
168.9
作者：
Black, Robert E.;Victora, Cesar G.;Uauy, Ricardo
通讯作者：
Uauy, Ricardo
影响因子：
4.7
作者：
Cheng, C-H;Chang, S-J;Huang, Y-C
通讯作者：
Huang, Y-C