Prevalence and associated birth outcomes of co-use of Cannabis and tobacco cigarettes during pregnancy.

Prevalence and associated birth outcomes of co-use of Cannabis and tobacco cigarettes during pregnancy.
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DOI:
10.1016/j.ntt.2018.06.001
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发表时间:
2018-07
影响因子:
2.9
通讯作者:
Mark K
Mark K
中科院分区:
医学3区
文献类型:
--
作者:
Coleman-Cowger VH;Oga EA;Peters EN;Mark K

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大麻的使用和烟草的使用重叠,大麻和烟草的共同使用在过去十年中在成人中有所增加。目前的研究旨在记录成年孕妇中大麻和烟草香烟共同使用的流行率和相关性,这些数据来自一项更大的研究,该研究比较并验证了怀孕期间非法和处方药使用的筛选器。2017年1月至12月期间,从两所城市大学产科诊所招募了孕妇(N=500; 71%为非洲裔美国人; 65%从未结婚,平均年龄28岁)。参与者自我报告人口统计学,大麻和烟草卷烟使用特征,并提供尿液和头发样本进行药物检测。在预产期后两周内,研究人员审查了参与者的电子病历,以收集出生结果数据。结果显示,9.0%的人报告同时使用大麻和烟草,12.1%的人报告仅使用大麻,7.8%的人报告仅使用烟草香烟,71.1%的人报告在过去一个月没有使用大麻或烟草香烟。与大麻和烟草香烟共同使用显著相关的出生结果是头围小和出生缺陷的发生,与其他使用组相比,共同使用组的头围小[aOR:5.7(1.1-28.9)]和出生缺陷[aOR:3.1(1.2-8.3)]的几率最高。仅使用大麻的组死胎或流产的几率高出12倍(aOR=12.1)。需要进行筛查和干预,以解决怀孕期间同时使用大麻和烟草的问题,特别是在同时使用率较高的亚人群中。鉴于本研究样本中发现的高流行率,必须进一步探讨和强调孕产妇共同使用可能对健康产生的影响。
Use of cannabis and use of tobacco overlap, and co-use of cannabis and tobacco has increased over the past decade among adults. The current study aims to document the prevalence and correlates of co-use of cannabis and tobacco cigarettes among adult pregnant women utilizing secondary data from a larger study that compared and validated screeners for illicit and prescription drug use during pregnancy. Pregnant women (N=500; 71% African American; 65% never married, average age of 28 years) were recruited from two urban University obstetric clinics between January and December 2017. Participants self-reported demographic, cannabis, and tobacco cigarette use characteristics, and provided urine and hair samples for drug testing. Within two weeks after due date, research staff reviewed participants’ electronic medical records to collect birth outcome data. Results showed that 9.0% reported co-use of cannabis and tobacco, 12.1% reported cannabis only use, 7.8% reported tobacco cigarette only use, and 71.1% reported no cannabis or tobacco cigarette use in the past month. The birth outcomes to emerge as significant correlates of co-use of cannabis and tobacco cigarettes were small head circumference, and the occurrence of birth defects, with the co-use group having the highest odds of a small head circumference [aOR: 5.7 (1.1–28.9)] and birth defects [aOR: 3.1 (1.2–8.3)] compared with other use groups. The cannabis only group had 12 times higher odds of a stillbirth or miscarriage (aOR=12.1). Screening and interventions to address concurrent cannabis and tobacco use during pregnancy are needed, particularly among subpopulations with higher co-use rates. It is imperative to further explore and highlight the possible health implications of maternal co-use given the high prevalence rates found in this study sample.
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