The surgically induced stress response.
The surgically induced stress response.
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DOI：
10.1177/0148607113496117
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Herndon DN
中科院分区：
文献类型：
--
作者：
Finnerty CC;Mabvuure NT;Ali A;Kozar RA;Herndon DN
对手术、危重病、创伤和烧伤的应激反应包括代谢和生理过程的紊乱，其诱导炎症、急性期、激素和基因组反应的扰动。结果是高代谢和高钙血症，导致肌肉萎缩、免疫功能受损和伤口愈合、器官衰竭和死亡。手术引起的应激反应在很大程度上类似于由创伤性损伤引发的应激反应;然而，应激反应的持续时间根据损伤的严重程度（手术或创伤）而变化。这种伤害和损伤的范围从小的撕裂伤到严重的损伤，如大的多发性创伤和烧伤。虽然对急性创伤的应激反应是为了提高受伤后的生存机会，但在现代外科实践中，应激反应可能是有害的。
The stress response to surgery, critical illness, trauma, and burns encompasses derangements of metabolic and physiological processes which induce perturbations in the inflammatory, acute phase, hormonal, and genomic responses. Hypermetabolism and hypercatabolism result, leading to muscle wasting, impaired immune function and wound healing, organ failure, and death. The surgery-induced stress response is largely similar to that triggered by traumatic injuries; the duration of the stress response, however, varies according to the severity of injury (surgical or traumatic). This spectrum of injuries and insults ranges from small lacerations to severe insults such as large poly-traumatic and burn injuries. Although the stress response to acute trauma evolved to improve chances of survival following injury, in modern surgical practice the stress response can be detrimental.
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DOI：
10.1097/bcr.0b013e3181db5317
发表时间：
2010-05
期刊：
Journal of burn care & research : official publication of the American Burn Association
影响因子：
--
作者：
Al-Mousawi AM;Williams FN;Mlcak RP;Jeschke MG;Herndon DN;Suman OE
通讯作者：
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DOI：
10.1097/ta.0b013e318031afd3
发表时间：
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影响因子：
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作者：
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1.3
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通讯作者：
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影响因子：
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