Evaluation of the fatty liver index as a predictor for the development of diabetes among insurance beneficiaries with prediabetes.
Evaluation of the fatty liver index as a predictor for the development of diabetes among insurance beneficiaries with prediabetes.
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DOI：
10.1111/jdi.12290
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发表时间：
2015-05
影响因子：
3.2
通讯作者：
Une H
中科院分区：
文献类型：
--
作者：
Nishi T;Babazono A;Maeda T;Imatoh T;Une H
非酒精性脂肪性肝病（NAFLD）是发达国家最常见的肝病，需要对糖尿病前期患者进行监测。然而，很少有报告建立糖尿病（DM）的风险与糖尿病前期患者。本研究的目的是评估NAFLD对糖尿病前期保险受益人糖尿病进展的影响，使用特定健康检查和脂肪肝指数（FLI）的数据。我们使用了一项回顾性队列研究，从两个健康保险协会招募了967名患有糖尿病前期的保险受益人，他们很少喝酒或不能喝酒，或者他们的酒精消费量<19 g/天。将保险受益人分为FLI <30、FLI ≥60和FLI> 30三组，随访3年后，采用多因素Logistic回归模型比较各组糖尿病发病率。在3年的随访中，65名男性（11.5%）和24名女性（6.0%）出现糖尿病进展。逻辑回归分析显示，NAFLD患者患DM的风险显着更高;男性（优势比2.68，95%置信区间1.29-5.56）和女性（优势比10.35，95%置信区间3.22-33.31）的情况都是如此。在患有前驱糖尿病的保险受益人中，患有NAFLD的人患糖尿病的风险显著高于没有NAFLD的人。FLI可能有助于检测糖尿病风险特别高的个体，并为在日本提供医疗保健服务制定更有效的指导。
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in developed countries, and it was required to monitor patients with prediabetes. However, there have been few reports establishing the risk for diabetes mellitus (DM) among patients with prediabetes. The purpose of the present study was to evaluate the effect of NAFLD on the progression of DM among insurance beneficiaries with prediabetes, using data from specific health check-ups and the fatty liver index (FLI). We used a retrospective cohort study that enrolled 967 insurance beneficiaries with prediabetes who had rarely drunk or could not drink alcohol, or whose alcohol consumption was <19 g/day from two health insurance societies. We divided insurance beneficiaries into FLI <30, intermediates FLIs and FLI ≥60, and compared the incidence rate of DM among the groups after 3 years' follow up, using multiple logistic regression models. During 3 years' follow up, progression of diabetes was seen in 65 men (11.5%) and 24 women (6.0%). Logistic regression analyses showed that those with NAFLD had significantly higher risks of developing DM; this was the case in both men (odds ratio 2.68, 95% confidential interval 1.29–5.56) and women (odds ratio 10.35, 95% confidential interval 3.22–33.31). Among insurance beneficiaries with prediabetes, those with NAFLD had a significantly higher risk of DM than those without NAFLD. The FLI might be useful for detecting individuals who have an especially higher risk for DM, and developing more effective guidance for delivering healthcare services in Japan.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
血红蛋白A1C和禁食等离子体葡萄糖定义的美国前糖尿病前期的世俗变化：国家健康和营养检查调查，1999-2010。
影响因子：
16.2
作者：
Bullard KM;Saydah SH;Imperatore G;Cowie CC;Gregg EW;Geiss LS;Cheng YJ;Rolka DB;Williams DE;Caspersen CJ
通讯作者：
Caspersen CJ
影响因子：
3.2
作者：
Mukai N;Doi Y;Ninomiya T;Hirakawa Y;Nagata M;Yoshida D;Hata J;Fukuhara M;Nakamura U;Kitazono T;Kiyohara Y
通讯作者：
Kiyohara Y
DOI：
10.1111/dme.12187
发表时间：
2013-08
期刊：
Diabetic medicine : a journal of the British Diabetic Association
影响因子：
--
作者：
Schneider AL;Lazo M;Ndumele CE;Pankow JS;Coresh J;Clark JM;Selvin E
通讯作者：
Selvin E
影响因子：
2.4
作者：
Balkau, Beverley;Lange, Celine;Bonnet, Fabrice
通讯作者：
Bonnet, Fabrice