Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: The Hisayama Study.

Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: The Hisayama Study.
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DOI:
10.1111/jdi.12136
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发表时间:
2014-03-23
影响因子:
3.2
通讯作者:
Kiyohara Y
Kiyohara Y
中科院分区:
医学3区
文献类型:
--
作者:
Mukai N;Doi Y;Ninomiya T;Hirakawa Y;Nagata M;Yoshida D;Hata J;Fukuhara M;Nakamura U;Kitazono T;Kiyohara Y

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我们研究了居住在社区的日本受试者中2型糖尿病和糖尿病前期患病率的长期趋势。1988年和2002年分别有2,490名和2,852名40-79岁的受试者接受了75 g口服葡萄糖耐量试验,其葡萄糖耐量状态由1998年世界卫生组织标准定义。从1988年到2002年,2型糖尿病的年龄调整患病率在男性(1988年的14.6%到2002年的20.8%,P < 0.001)和女性(1988年的9.1%到2002年的11.2%,P = 0.002)中显著增加。在男性和女性中,经年龄调整的糖尿病前期患病率也显着上升(男性从1988年的26.2%上升到2002年的35.3%,P < 0.001;女性从1988年的22.5%上升到2002年的25.1%,P = 0.04)。在年龄分层分析中,2型糖尿病的患病率在60-69岁和70-79岁的男性(均P < 0.001)和70 -79岁的女性(P = 0.02)中随时间显著增加。从1988年到2002年,60-69岁和70-79岁的男性和70 - 79岁的女性的整体和中心性肥胖的患病率显著增加,而70-79岁的男性在两次调查之间的定期锻炼频率显著下降。我们的研究结果表明,从20世纪80年代到21世纪初,日本普通人群中2型糖尿病和前驱糖尿病的患病率在男性和女性中均显着增加,肥胖患病率的增加和体力活动的减少对这种上升趋势产生了影响。
We examined secular trends in the prevalence of type 2 diabetes and prediabetes in community‐dwelling Japanese subjects. A total of 2,490 subjects in 1988 and 2,852 subjects in 2002 aged 40–79 years underwent a 75‐g oral glucose tolerance test, and their glucose tolerance status was defined by the 1998 World Health Organization criteria. The age‐adjusted prevalence of type 2 diabetes increased significantly from 1988 to 2002 in men (14.6% in 1988 to 20.8% in 2002, P < 0.001) and women (9.1% in 1988 to 11.2% in 2002, P = 0.002). A significant rise in the age‐adjusted prevalence of prediabetes was also observed in both sexes (26.2% in 1988 to 35.3% in 2002, P < 0.001 for men; 22.5% in 1988 to 25.1% in 2002, P = 0.04 for women). In age‐stratified analysis, the prevalence of type 2 diabetes increased markedly over time in men aged 60–69 and 70–79 years (both P < 0.001) and women aged 70–79 years (P = 0.02). The prevalence of overall and central obesity increased significantly in men aged 60–69 and 70–79 years, and women aged 70–79 years from 1988 to 2002, whereas the frequency of regular exercise decreased significantly in men aged 70–79 years between the surveys. Our findings suggest that the prevalence of type 2 diabetes and prediabetes increased significantly in both sexes from the 1980s to the 2000s in a general Japanese population, and that the increasing prevalence of obesity and the decline in physical activity exerted an influence on this rising trend.
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