Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart Family Study.
Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart Family Study.
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DOI：
10.1007/s00125-013-2988-8
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发表时间：
2013-10
期刊：
影响因子：
8.2
通讯作者：
Cole, S. A.
中科院分区：
文献类型：
--
作者：
Franceschini, N.;Haack, K.;Goering, H. H. H.;Voruganti, V. S.;Laston, S.;Almasy, L.;Lee, E. T.;Best, L. G.;Fabsitz, R. R.;North, K. E.;MacCluer, J. W.;Meigs, J. B.;Pankow, J. S.;Cole, S. A.
2型糖尿病是一种慢性异质性疾病，是心血管疾病的主要危险因素。导致2型糖尿病进展的潜在机制尚不完全清楚，遗传工具可能有助于确定血糖恶化的重要途径。使用来自强心脏家族研究的美国印第安人的前瞻性数据，我们确定了373名被定义为进展者（糖尿病事件病例），566名短暂性空腹血糖受损（IFG）和1011名对照组（所有就诊时空腹血糖正常）。我们估计了这些性状的遗传力（h2）以及与2型糖尿病全基因组关联研究中发现的16种已知变异相关的证据。我们注意到糖尿病进展的高h2 (h2=0.65±0.16,p=2.7×10−6)，但遗传因素对短暂IFG的贡献很小（h2=0.09±0.10,p=0.19）。在年龄和性别调整分析中，至少有三种变异（WFS1、TSPAN8和THADA）在名义上与糖尿病进展有关，估计显示与发现欧洲血统研究中报道的影响方向相同。我们的研究结果并没有排除美洲印第安人糖尿病易感性的这些基因位点，并表明IFG性状的表型异质性，当诊断基于单一时间点测量时，这可能对遗传学研究有影响。
Type 2 diabetes is a chronic, heterogeneous disease and a major risk factor for cardiovascular diseases. The underlying mechanisms leading to progression to type 2 diabetes are not fully understood and genetic tools may help to identify important pathways of glycaemic deterioration. Using prospective data on American Indians from the Strong Heart Family Study, we identified 373 individuals defined as progressors (diabetes incident cases), 566 individuals with transitory impaired fasting glucose (IFG) and 1,011 controls (normal fasting glycaemia at all visits). We estimated the heritability (h2) of the traits and the evidence for association with 16 known variants identified in type 2 diabetes genome-wide association studies. We noted high h2 for diabetes progression (h2=0.65±0.16, p=2.7×10−6) but little contribution of genetic factors to transitory IFG (h2=0.09±0.10, p=0.19) for models adjusted for multiple risk factors. At least three variants (in WFS1, TSPAN8 and THADA) were nominally associated with diabetes progression in age- and sex-adjusted analyses with estimates showing the same direction of effects as reported in the discovery European ancestry studies. Our findings do not exclude these loci for diabetes susceptibility in American Indians and suggest phenotypic heterogeneity of the IFG trait, which may have implications for genetic studies when diagnosis is based on a single time-point measure.
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全基因组关联研究的荟萃分析确定了东亚人 2 型糖尿病的 8 个新位点
影响因子：
30.8
作者：
Cho, Yoon Shin;Chen, Chien-Hsiun;Hu, Cheng;Long, Jirong;Ong, Rick Twee Hee;Sim, Xueling;Takeuchi, Fumihiko;Wu, Ying;Go, Min Jin;Yamauchi, Toshimasa;Chang, Yi-Cheng;Kwak, Soo Heon;Ma, Ronald C. W.;Yamamoto, Ken;Adair, Linda S.;Aung, Tin;Cai, Qiuyin;Chang, Li-Ching;Chen, Yuan-Tsong;Gao, Yutang;Hu, Frank B.;Kim, Hyung-Lae;Kim, Sangsoo;Kim, Young Jin;Lee, Jeannette Jen-Mai;Lee, Nanette R.;Li, Yun;Liu, Jian Jun;Lu, Wei;Nakamura, Jiro;Nakashima, Eitaro;Ng, Daniel Peng-Keat;Tay, Wan Ting;Tsai, Fuu-Jen;Wong, Tien Yin;Yokota, Mitsuhiro;Zheng, Wei;Zhang, Rong;Wang, Congrong;So, Wing Yee;Ohnaka, Keizo;Ikegami, Hiroshi;Hara, Kazuo;Cho, Young Min;Cho, Nam H.;Chang, Tien-Jyun;Bao, Yuqian;Hedman, Asa K.;Morris, Andrew P.;McCarthy, Mark I.;Takayanagi, Ryoichi;Park, Kyong Soo;Jia, Weiping;Chuang, Lee-Ming;Chan, Juliana C. N.;Maeda, Shiro;Kadowaki, Takashi;Lee, Jong-Young;Wu, Jer-Yuarn;Teo, Yik Ying;Tai, E. Shyong;Shu, Xiao Ou;Mohlke, Karen L.;Kato, Norihiro;Han, Bok-Ghee;Seielstad, Mark
通讯作者：
Seielstad, Mark
影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
16.2
作者：
Hemminki K;Li X;Sundquist K;Sundquist J
通讯作者：
Sundquist J
影响因子：
16.2
作者：
Haas, Linda;Maryniuk, Melinda;Youssef, Gretchen
通讯作者：
Youssef, Gretchen
影响因子：
8.2
作者：
Cheurfa, N.;Brenner, G. M.;Velho, G.
通讯作者：
Velho, G.