Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
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全基因组关联研究的荟萃分析确定了东亚人 2 型糖尿病的 8 个新位点
DOI：
10.1038/ng.1019
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发表时间：
2011-12-11
期刊：
影响因子：
30.8
通讯作者：
Seielstad, Mark
中科院分区：
文献类型：
--
作者：
Cho, Yoon Shin;Chen, Chien-Hsiun;Hu, Cheng;Long, Jirong;Ong, Rick Twee Hee;Sim, Xueling;Takeuchi, Fumihiko;Wu, Ying;Go, Min Jin;Yamauchi, Toshimasa;Chang, Yi-Cheng;Kwak, Soo Heon;Ma, Ronald C. W.;Yamamoto, Ken;Adair, Linda S.;Aung, Tin;Cai, Qiuyin;Chang, Li-Ching;Chen, Yuan-Tsong;Gao, Yutang;Hu, Frank B.;Kim, Hyung-Lae;Kim, Sangsoo;Kim, Young Jin;Lee, Jeannette Jen-Mai;Lee, Nanette R.;Li, Yun;Liu, Jian Jun;Lu, Wei;Nakamura, Jiro;Nakashima, Eitaro;Ng, Daniel Peng-Keat;Tay, Wan Ting;Tsai, Fuu-Jen;Wong, Tien Yin;Yokota, Mitsuhiro;Zheng, Wei;Zhang, Rong;Wang, Congrong;So, Wing Yee;Ohnaka, Keizo;Ikegami, Hiroshi;Hara, Kazuo;Cho, Young Min;Cho, Nam H.;Chang, Tien-Jyun;Bao, Yuqian;Hedman, Asa K.;Morris, Andrew P.;McCarthy, Mark I.;Takayanagi, Ryoichi;Park, Kyong Soo;Jia, Weiping;Chuang, Lee-Ming;Chan, Juliana C. N.;Maeda, Shiro;Kadowaki, Takashi;Lee, Jong-Young;Wu, Jer-Yuarn;Teo, Yik Ying;Tai, E. Shyong;Shu, Xiao Ou;Mohlke, Karen L.;Kato, Norihiro;Han, Bok-Ghee;Seielstad, Mark
我们进行了一项三阶段遗传学研究，以确定东亚人群中2型糖尿病（T2 D）的易感基因位点。我们对8项T2 D全基因组关联研究（6，952例T2 D病例和11，865例对照）进行了第1阶段荟萃分析，并进行了第2阶段硅复制分析（5，843例病例和4，574例对照）和第3阶段novorepreplication分析（12，284例病例和13，172例对照）。这些位点位于GLIS 3、PEPD、FITM 2-R3 HDML-HNF 4A、KCNK 16、MAEA、GCC 1-PAX 4、PSMD 6和ZFAND 3等位点附近。GLIS 3与胰岛β细胞发育和胰岛素基因表达有关，与空腹血糖水平相关。先前的研究已经证明PEPD和HNF 4A与2型糖尿病相关，KCNK 16可能调节胰腺葡萄糖依赖性胰岛素分泌。这些来自东亚人群的发现为T2 D的病因学提供了新的视角。
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2in silicoreplication analysis (5,843 cases and 4,574 controls) and a stage 3de novoreplication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or nearGLIS3,PEPD,FITM2-R3HDML-HNF4A,KCNK16,MAEA,GCC1-PAX4,PSMD6andZFAND3.GLIS3, which is involved in pancreatic beta cell development and insulin gene expression,, is known for its association with fasting glucose levels,. The evidence of an association with T2D forPEPDandHNF4A,has been shown in previous studies.KCNK16may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D.
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DOI：
10.1016/j.tig.2008.09.004
发表时间：
2008-12
期刊：
Trends in genetics : TIG
影响因子：
--
作者：
Prokopenko I;McCarthy MI;Lindgren CM
通讯作者：
Lindgren CM
影响因子：
4.5
作者：
Shu XO;Long J;Cai Q;Qi L;Xiang YB;Cho YS;Tai ES;Li X;Lin X;Chow WH;Go MJ;Seielstad M;Bao W;Li H;Cornelis MC;Yu K;Wen W;Shi J;Han BG;Sim XL;Liu L;Qi Q;Kim HL;Ng DP;Lee JY;Kim YJ;Li C;Gao YT;Zheng W;Hu FB
通讯作者：
Hu FB
影响因子：
7.7
作者：
Barker A;Sharp SJ;Timpson NJ;Bouatia-Naji N;Warrington NM;Kanoni S;Beilin LJ;Brage S;Deloukas P;Evans DM;Grontved A;Hassanali N;Lawlor DA;Lecoeur C;Loos RJ;Lye SJ;McCarthy MI;Mori TA;Ndiaye NC;Newnham JP;Ntalla I;Pennell CE;St Pourcain B;Prokopenko I;Ring SM;Sattar N;Visvikis-Siest S;Dedoussis GV;Palmer LJ;Froguel P;Smith GD;Ekelund U;Wareham NJ;Langenberg C
通讯作者：
Langenberg C
影响因子：
30.8
作者：
Barrett, Jeffrey C.;Clayton, David G.;Concannon, Patrick;Akolkar, Beena;Cooper, Jason D.;Erlich, Henry A.;Julier, Cecile;Morahan, Grant;Nerup, Jorn;Nierras, Concepcion;Plagnol, Vincent;Pociot, Flemming;Schuilenburg, Helen;Smyth, Deborah J.;Stevens, Helen;Todd, John A.;Walker, Neil M.;Rich, Stephen S.
通讯作者：
Rich, Stephen S.
影响因子：
7.7
作者：
Johansson, Stefan;Raeder, Helge;Njolstad, Pal Rasmus
通讯作者：
Njolstad, Pal Rasmus