Identification of a novel link between adiposity and visuospatial perception.
Identification of a novel link between adiposity and visuospatial perception.
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DOI：
10.1002/oby.23603
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发表时间：
2023-02
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影响因子：
--
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最近的研究报告了BMI和Penn Line Orientation Task（PLOT）的表现之间的负相关。为了确定这种效应的可靠性，我们对健康体重（HW）和超重/肥胖（OW/OB）个体的视功能进行了全面评估。在80例（40例HW，40例OW/OB）病例对照研究参与者中测量了视力/对比度，PLOT和高阶视觉空间功能。还评估了肥胖、空腹胰岛素、HbA 1c、饮食、体力活动和心率变异性。一个亚组的22名参与者加上5个额外的个人（n=27）进行了功能磁共振成像扫描。与HW相比，OW/OB的个人在需要判断线方向的任务上表现更差。这种影响是由体脂百分比介导的，与其他措施无关。功能磁共振成像显示，BMI和初级视觉皮层（V1）的反应线方向判断呈负相关。表现与V1反应无关，但当模型中考虑BMI时，与包括外侧枕叶皮质在内的区域网络中的反应呈正相关。我们的研究结果表明，与肥胖和钝化激活VI，不能归因于视敏度和不概括到其他视觉空间任务的线方向知觉的选择性赤字。
Recent work has reported a negative association between BMI and performance on the Penn Line Orientation Task (PLOT). To determine the reliability of this effect, we performed a comprehensive assessment of visual function in individuals with healthy weight (HW) and overweight/obesity (OW/OB). Visual acuity/contrast, PLOT, and higher-order visuospatial function were measured in 80 (40 HW, 40 OW/OB) case-control study participants. Adiposity, fasting insulin, HbA1c, diet, physical activity and heart rate variability were also assessed. A subgroup of 22 participants plus 5 additional individuals (n=27) underwent fMRI scanning. Compared to HW, individuals with OW/OB performed worse on tasks requiring judgements of line orientation. This effect was mediated by percent body fat and unrelated to other measures. fMRI revealed a negative association between BMI and response in the primary visual cortex (V1) during line orientation judgement. Performance was unrelated to V1 response, but positively correlated with response in a network of regions, including the lateral occipital cortex, when BMI was accounted for in the model. Our results demonstrate a selective deficit in line orientation perception associated with adiposity and blunted activation in VI, that cannot be attributed to visual acuity and does not generalize to other visuospatial tasks.
影响因子：
3.1
作者：
Gess, Jennifer L.;Fausett, Jennifer S.;Kearney-Ramos, Tonisha E.;Kilts, Clinton D.;James, George Andrew
通讯作者：
James, George Andrew