Task-dependent recruitment of intrinsic brain networks reflects normative variance in cognition.
Task-dependent recruitment of intrinsic brain networks reflects normative variance in cognition.
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DOI：
10.1002/brb3.243
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发表时间：
2014-09
影响因子：
3.1
通讯作者：
James, George Andrew
中科院分区：
文献类型：
--
作者：
Gess, Jennifer L.;Fausett, Jennifer S.;Kearney-Ramos, Tonisha E.;Kilts, Clinton D.;James, George Andrew
功能性神经影像学具有很大的潜力，可以为临床决策提供信息，无论是通过识别疾病进展和严重程度的神经生物标志物，预测治疗反应，还是选择合适的患者进行手术干预。然而，功能性神经影像学临床转化的一个持续障碍是我们对认知、人格和行为的规范性差异如何塑造大脑的结构和功能组织的不完全理解。我们建议，在这些脑行为关系中建模个体差异对于提高神经和精神疾病的神经影像学生物标志物的准确性至关重要。我们通过启动认知连接组项目来实现这一目标，该项目将神经心理学和神经影像学联系起来，将通常由临床验证的神经心理学测量评估的九个认知领域与经典神经影像学任务（运动、视觉空间感知、注意力、语言、记忆、情感处理、决策、工作记忆和执行功能）相结合。到目前为止，我们已经招募了53名参与者的多样化样本（平均值[SD]，年龄= 32 [9.7]岁，31名女性）。作为概念的证明，我们首先证明了我们的神经成像任务电池可以复制以前的研究结果，即任务表现招募在清醒休息期间识别的内在大脑网络。然后，我们扩大了这些以前的研究结果表明，在何种程度上，这些网络被招募的任务反映了认知能力的个体差异。具体而言，在MRI扫描仪外执行的线方向判断任务（一种临床验证的视觉空间感知测量）的表现预测了在MRI扫描仪内执行该任务的直接复制时背侧视觉网络的任务诱导活动的幅度。其他网络（如默认模式和右额顶叶）显示任务引起的活动与任务表现无关的变化，这表明这些网络不参与视觉空间感知。这些发现建立了一个方法框架，临床神经心理学和功能神经影像学可以相互告知对方，从而提高翻译功能神经影像学临床决策。
Functional neuroimaging has great potential to inform clinical decisions, whether by identifying neural biomarkers of illness progression and severity, predicting therapeutic response, or selecting suitable patients for surgical interventions. Yet a persisting barrier to functional neuroimaging's clinical translation is our incomplete understanding of how normative variance in cognition, personality, and behavior shape the brain's structural and functional organization. We propose that modeling individual differences in these brain–behavior relationships is crucial for improving the accuracy of neuroimaging biomarkers for neurologic and psychiatric disorders. We addressed this goal by initiating the Cognitive Connectome Project, which bridges neuropsychology and neuroimaging by pairing nine cognitive domains typically assessed by clinically validated neuropsychological measures with those tapped by canonical neuroimaging tasks (motor, visuospatial perception, attention, language, memory, affective processing, decision making, working memory, and executive function). To date, we have recruited a diverse sample of 53 participants (mean [SD], age = 32 [9.7] years, 31 females). As a proof of concept, we first demonstrate that our neuroimaging task battery can replicate previous findings that task performance recruits intrinsic brain networks identified during wakeful rest. We then expand upon these previous findings by showing that the extent to which these networks are recruited by task reflects individual differences in cognitive ability. Specifically, performance on the Judgment of Line Orientation task (a clinically validated measure of visuospatial perception) administered outside of the MRI scanner predicts the magnitude of task-induced activity of the dorsal visual network when performing a direct replication of this task within the MRI scanner. Other networks (such as default mode and right frontoparietal) showed task-induced changes in activity that were unrelated to task performance, suggesting these networks to not be involved in visuospatial perception. These findings establish a methodological framework by which clinical neuropsychology and functional neuroimaging may mutually inform one another, thus enhancing the translation of functional neuroimaging into clinical decision making.
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影响因子：
56.9
作者：
Büchel, C;Coull, JT;Friston, KJ
通讯作者：
Friston, KJ
影响因子：
14.5
作者：
Catalan, MJ;Honda, M;Hallett, M
通讯作者：
Hallett, M
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1076/jcen.24.5.586.1006
发表时间：
2002-01-01
影响因子：
2.2
作者：
Berg, WK;Byrd, DL
通讯作者：
Byrd, DL
DOI：
10.1523/jneurosci.5319-08.2009
发表时间：
2009-07-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bickel WK;Pitcock JA;Yi R;Angtuaco EJ
通讯作者：
Angtuaco EJ