Understanding the DNA damage response in order to achieve desired gene editing outcomes in mosquitoes.
Understanding the DNA damage response in order to achieve desired gene editing outcomes in mosquitoes.
复制标题
DOI：
10.1007/s10577-014-9450-8
复制
发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Adelman ZN
中科院分区：
文献类型：
--
作者：
Overcash JM;Aryan A;Myles KM;Adelman ZN
Mosquitoes are high-impact disease vectors with the capacity to transmit pathogenic agents that cause diseases such as malaria, yellow fever, chikungunya, and dengue. Continued growth in knowledge of genetic, molecular, and physiological pathways in mosquitoes allows for the development of novel control methods and for the continued optimization of existing ones. The emergence of site-specific nucleases as genomic engineering tools promises to expedite research of crucial biological pathways in these disease vectors. The utilization of these nucleases in a more precise and efficient manner is dependent upon knowledge and manipulation of the DNA repair pathways utilized by the mosquito. While progress has been made in deciphering DNA repair pathways in some model systems, research into the nature of the hierarchy of mosquito DNA repair pathways, as well as in mechanistic differences that may exist, is needed. In this review, we will describe progress in the use of site-specific nucleases in mosquitoes, along with the hierarchy of DNA repair in the context of mosquito chromosomal organization and structure, and how this knowledge may be manipulated to achieve precise chromosomal engineering in mosquitoes.
登录
查看更多内容
影响因子：
2.6
作者：
Casso, David;Ramirez-Weber, Felipe-Andres;Kornberg, Thomas B.
通讯作者：
Kornberg, Thomas B.
影响因子：
9.2
作者：
Ciapponi, L;Cenci, G;Gatti, M
通讯作者：
Gatti, M
影响因子：
3.8
作者：
Clements, PM;Breslin, C;Caldecott, KW
通讯作者：
Caldecott, KW
DOI：
10.1038/mtna.2011.5
发表时间：
2012-01-24
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1073/pnas.1404996111
发表时间：
2014-05-27
影响因子：
11.1
作者：
Bernardini, Federica;Galizi, Roberto;Windbichler, Nikolai
通讯作者：
Windbichler, Nikolai