Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report.
Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report.
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DOI：
10.3389/fneur.2022.1002076
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发表时间：
2022
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
--
作者：
嗅觉神经母细胞瘤（ONB）引起的副肿瘤性周围神经病变（PPN）尚未报道。我们提出一个罕见的情况下，一个成年人谁住院反复在过去9个月的持续疼痛和麻木的四肢。该患者最初被诊断为慢性炎性脱髓鞘性多发性神经病（CIDP）并进行了相应的治疗，但神经系统症状没有明显改善。入院后，FDG-PET/CT显示鼻腔内软组织肿块局灶性高代谢，进一步病变活检提示ONB。结合血清抗Hu抗体阳性，最终诊断为PPN合并ONB。此外，患者的神经系统症状在原发肿瘤切除后缓解，证实了诊断的准确性。我们的病例不仅扩大了ONB的临床特征，而且强调了早期和全面的肿瘤筛查对诊断PPN的重要性。
Paraneoplastic peripheral neuropathy (PPN) caused by olfactory neuroblastoma (ONB) has not yet been reported. We present a rare case of an adult who hospitalized repeatedly over the past 9 months for persistent pain and numbness in the limbs. This patient was initially diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP) and treated accordingly, but neurological symptoms did not improve significantly. After this admission, FDG-PET/CT showed focal hypermetabolism of a soft-tissue mass in the nasal cavity, and further lesion biopsy suggested ONB. Combined with positive serum anti-Hu antibody, the diagnosis of PPN associated with ONB was eventually made. Furthermore, the patient's neurological symptoms were relieved after removal of the primary tumor, confirming the accuracy of the diagnosis. Our case not only expanded the clinical characteristics of ONB but also highlighted the importance of early and comprehensive tumor screening for the diagnosis of PPN.
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