Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients.
Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients.
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DOI：
10.1016/j.ajo.2018.02.002
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发表时间：
2018-05
影响因子：
4.2
通讯作者：
Weinreb RN
中科院分区：
文献类型：
--
作者：
Hou H;Shoji T;Zangwill LM;Moghimi S;Saunders LJ;Hasenstab K;Ghahari E;Manalastas PIC;Akagi T;Christopher M;Penteado RC;Weinreb RN
比较伴有或不伴有2型糖尿病（DM）的原发性开角型青光眼（POAG）患者视野（VF）丧失和视网膜神经纤维层（RNFL）变薄的发生率。队列研究。青光眼诊断创新研究（DIGS）共纳入197只眼（POAG/DM组32例合并DM的POAG患者55只眼，POAG/DM-组111例年龄匹配的无DM的POAG患者142只眼）。2型糖尿病参与者通过自我报告糖尿病病史和使用抗糖尿病药物来定义。采用单变量和多变量混合效应模型比较有和无DM的POAG眼的VF损失率和RNFL损失率。中位（四分位间距）随访时间为5.7年（4.0年，6.4年）。POAG/DM组总体RNFL平均损失率比POAG/DM组慢2倍（- 0.40µm/年vs - 0.83µm/年，P = 0.01）。虽然与POAG/DM-组相比，POAG/DM组的VF平均偏差和模式标准差损失速率较慢，但差异无统计学意义。与未诊断为糖尿病的POAG患者相比，未检测到糖尿病视网膜病变的2型糖尿病患者的RNFL变薄率明显较慢。
To compare the rates of visual field (VF) loss and retinal nerve fiber layer (RNFL) thinning in primary open angle glaucoma (POAG) patients with or without type 2 diabetes mellitus (DM). Cohort study. A total of 197 eyes (55 eyes of 32 POAG patients with DM in POAG/DM group and 142 eyes of 111 age-matched POAG patients without DM in POAG/DM- group) were included from the Diagnostic Innovations in Glaucoma Study (DIGS). Type 2 DM participants were defined by self-report of DM history and use of anti-diabetic medication. The rates of VF loss and RNFL loss were compared in POAG eyes with and without DM using univariate and multivariable mixed effects models. The median (interquartile range) follow-up was 5.7 years (4.0, 6.4). The mean rate of global RNFL loss in the POAG/DM group was 2-fold slower than in the POAG/DM- group overall (−0.40 µm/year vs. −0.83 µm/year, respectively P = 0.01). Although a slower rate of VF mean deviation and pattern standard deviation loss was found in the POAG/DM group compared to the POAG/DM- group, the difference was not statistically significant. POAG patients with treated type 2 DM, who had no detectable diabetic retinopathy, had significantly slower rates of RNFL thinning compared to those without diagnosed DM.
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影响因子：
4.3
作者：
Hernández C;Dal Monte M;Simó R;Casini G
通讯作者：
Casini G
影响因子：
2
作者：
Akkaya, Serkan;Can, Ertugrul;Ozturk, Faruk
通讯作者：
Ozturk, Faruk
影响因子：
4.4
作者：
Gardiner SK;Mansberger SL
通讯作者：
Mansberger SL
DOI：
10.1159/000442801
发表时间：
2016-01-01
期刊：
OCT ANGIOGRAPHY IN RETINAL AND MACULAR DISEASES
影响因子：
--
作者：
Bandello, F.;Corbelli, Eleonora;Querques, G.
通讯作者：
Querques, G.
影响因子：
13.7
作者：
Chopra, Vikas;Varma, Rohit;Azen, Stanley P.
通讯作者：
Azen, Stanley P.