Laboratory models of post-traumatic stress disorder: The elusive bridge to translation.
Laboratory models of post-traumatic stress disorder: The elusive bridge to translation.
复制标题
创伤后应激障碍的实验室模型：难以捉摸的翻译桥梁。
DOI：
10.1016/j.neuron.2022.03.001
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发表时间：
2022-06-01
期刊：
影响因子：
16.2
通讯作者：
Nemeroff, Charles B.
中科院分区：
文献类型：
--
作者：
Dunsmoor, Joseph E.;Cisler, Josh M.;Fonzo, Gregory A.;Creech, Suzannah K.;Nemeroff, Charles B.
Posttraumatic stress disorder (PTSD) is a debilitating mental illness composed of a heterogeneous collection of symptom clusters. The unique nature of PTSD as arising from a precipitating traumatic event helps simplify cross-species translational research modeling the neurobehavioral effects of stress and fear. However, neurobiological progress on these complex neural circuits informed by animal models has yet to produce novel evidence-based clinical treatment for PTSD. Here, we provide a comprehensive overview of popular laboratory models of PTSD and provide concrete ideas for improving validity and clinical translational value of basic research efforts in humans. We detail modifications to simplified animal paradigms to account for myriad cognitive factors affected in PTSD, which may contribute to abnormalities in regulating fear. We further describe new avenues for integrating different areas of psychological research underserved by animal models of PTSD. This includes incorporating emerging trends in the cognitive neuroscience of episodic memory, emotion regulation, social-emotional processes, and PTSD subtyping to provide a more comprehensive recapitulation of the human experience to trauma in laboratory research. Dunsmoor et al. detail challenges to cross-translation of laboratory PTSD models from laboratory animals to humans, and describe approaches to enrich laboratory paradigms in humans to account for myriad cognitive, social, and emotional factors affected in PTSD.
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影响因子：
56.9
作者：
Blaisdell, AP;Sawa, K;Waldmann, MR
通讯作者：
Waldmann, MR
影响因子：
4.1
作者：
Brewin, CR
通讯作者：
Brewin, CR
影响因子：
4.6
作者：
Andrews, Bernice;Brewin, Chris R.;Hejdenberg, Jennie
通讯作者：
Hejdenberg, Jennie
影响因子：
64.5
作者：
Anderson DJ;Adolphs R
通讯作者：
Adolphs R
DOI：
10.1523/jneurosci.1524-11.2011
发表时间：
2011-06-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bach DR;Weiskopf N;Dolan RJ
通讯作者：
Dolan RJ