Immune recognition and rejection of allogeneic skin grafts.
Immune recognition and rejection of allogeneic skin grafts.
复制标题
DOI：
10.2217/imt.11.2
复制
发表时间：
2011-06
期刊：
影响因子：
2.8
通讯作者：
Tocco G
中科院分区：
文献类型：
--
作者：
Benichou G;Yamada Y;Yun SH;Lin C;Fray M;Tocco G
同种异体皮肤移植物的移植与导致供体细胞破坏和移植物排斥的强炎症免疫应答相关。移植后不久，皮肤树突状细胞（DC）通过淋巴管迁移出移植物并浸润受体的引流淋巴结，在那里它们通过两种机制呈递供体抗原：直接途径，其中T细胞识别供体DC上的完整供体MHC抗原;和间接途径，涉及T细胞识别与受体DC上的自身MHC分子结合的供体肽。最近的一些研究表明，T细胞可以通过识别受体抗原呈递细胞上转移的供体MHC分子（半直接途径）而被激活。通过直接或间接的同种异体识别激活T细胞足以引发同种异体皮肤移植物的急性排斥反应。此外，同种特异性抗体通过以补体依赖性方式杀死同种异体靶标或通过调理供体细胞并形成免疫复合物来促进排斥过程。最后，几项研究表明，由于同种异体细胞上缺少自身MHC I类分子而激活的NK细胞通过直接杀死供体细胞和通过产生促炎细胞因子（包括IFN-γ和TNF-α）参与同种异体皮肤移植物排斥反应。
The transplantation of allogeneic skin grafts is associated with a potent infammatory immune response leading to the destruction of donor cells and the rejection of the graft. Shortly after transplantation, skin dendritic cells (DCs) migrate out of the graft through lymphatic vessels and infiltrate the recipient’s draining lymph nodes where they present donor antigens via two mechanisms: the direct pathway, in which T cells recognize intact donor MHC antigens on donor DCs; and the indirect pathway, involving T-cell recognition of donor peptides bound to self-MHC molecules on recipient DCs. Some recent studies have suggested that T cells can become activated via recognition of donor MHC molecules transferred on recipient antigen-presenting cells (semidirect pathway). Activation of T cells via direct or indirect allorecognition is sufficient to trigger acute rejection of allogeneic skin grafts. In addition, allospecific antibodies contribute to the rejection process either by killing allogeneic targets in a complement-dependent fashion or by opsonizing donor cells and forming immune complexes. Finally, several studies demonstrate that NK cells, activated due to missing self-MHC class I molecules on allogeneic cells, are involved in allogeneic skin graft rejection via direct killing of donor cells and through the production of proinflammatory cytokines including IFN-γ and TNF-α.
登录
查看更多内容
DOI：
10.1084/jem.20021910
发表时间：
2003-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Curtsinger JM;Lins DC;Mescher MF
通讯作者：
Mescher MF
Langerhans细胞（LC）增殖介导了新生儿发育，体内平衡和与表皮LC网络的炎症相关扩张。
DOI：
10.1084/jem.20091586
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chorro L;Sarde A;Li M;Woollard KJ;Chambon P;Malissen B;Kissenpfennig A;Barbaroux JB;Groves R;Geissmann F
通讯作者：
Geissmann F
影响因子：
6.2
作者：
Boisgérault F;Liu Y;Anosova N;Dana R;Benichou G
通讯作者：
Benichou G
影响因子：
4.4
作者：
BENICHOU, G;FEDOSEYEVA, E;SERCARZ, EE
通讯作者：
SERCARZ, EE
影响因子：
4.4
作者：
BREURVRIESENDORP, BS;IVANYI, P
通讯作者：
IVANYI, P