Classifying the unclassifiable-a Delphi study to reach consensus on the fibrotic nature of diseases.
Classifying the unclassifiable-a Delphi study to reach consensus on the fibrotic nature of diseases.
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DOI：
10.1093/qjmed/hcad050
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发表时间：
2023-06-08
影响因子：
13.3
通讯作者：
Quint, J. K.
中科院分区：
文献类型：
--
作者：
Massen, G. M.;Allen, R. J.;Leavy, O. C.;Selby, N. M.;Aithal, G. P.;Oliver, N.;Parfrey, H.;Wain, L., V;Jenkins, G.;Stewart, I;Quint, J. K.
传统上，临床研究集中在单个纤维化疾病或特定器官中的纤维化。然而，人们可能患有多种纤维化疾病。虽然多器官纤维化可能表明共同的致病机制，但对于什么构成纤维化疾病并因此构成纤维化多发性硬化没有共识。进行了一项德尔菲研究，以就哪些疾病可被描述为纤维化达成共识。参与者被要求对一系列疾病进行评级，根据八个身体区域进行分组，如“纤维化表现总是存在”，“可以发展纤维化表现”，“与纤维化表现相关”或“不纤维化也不相关”。合并了“始终存在纤维化表现”和“可能出现纤维化表现”的分类，并将其称为“纤维化”。根据四分位数间距定义临床共识，满足最小数量的响应。临床一致性用于分类，其中疾病不符合最低应答数量（共识测量所需），仅在疾病分类100%一致时进行分类。在咨询专家、检索文献和编码词典后，共确定了323种可能被认为是纤维化的非重叠疾病; 92名临床专家对第一轮调查做出了回应。在三轮调查中，240种疾病通过临床共识被归类为纤维化，另外25种疾病通过临床共识被归类为纤维化。使用一种强有力的方法，对一系列广泛的疾病进行了分类。这些发现为估计纤维化多发性硬化的负担以及调查共同机制和治疗方法的研究奠定了基础。
Traditionally, clinical research has focused on individual fibrotic diseases or fibrosis in a particular organ. However, it is possible for people to have multiple fibrotic diseases. While multi-organ fibrosis may suggest shared pathogenic mechanisms, yet there is no consensus on what constitutes a fibrotic disease and therefore fibrotic multimorbidity. A Delphi study was performed to reach consensus on which diseases may be described as fibrotic. Participants were asked to rate a list of diseases, sub-grouped according to eight body regions, as ‘fibrotic manifestation always present’, ‘can develop fibrotic manifestations’, ‘associated with fibrotic manifestations’ or ‘not fibrotic nor associated’. Classifications of ‘fibrotic manifestation always present’ and ‘can develop fibrotic manifestations’ were merged and termed ‘fibrotic’. Clinical consensus was defined according to the interquartile range, having met a minimum number of responses. Clinical agreement was used for classification where diseases did not meet the minimum number of responses (required for consensus measure), were only classified if there was 100% consensus on disease classification. After consulting experts, searching the literature and coding dictionaries, a total of 323 non-overlapping diseases which might be considered fibrotic were identified; 92 clinical specialists responded to the first round of the survey. Over three survey rounds, 240 diseases were categorized as fibrotic via clinical consensus and 25 additional diseases through clinical agreement. Using a robust methodology, an extensive list of diseases was classified. The findings lay the foundations for studies estimating the burden of fibrotic multimorbidity, as well as investigating shared mechanisms and therapies.
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影响因子：
3.9
作者：
Piera-Velazquez S;Mendoza FA;Jimenez SA
通讯作者：
Jimenez SA
DOI：
10.2147/copd.s287705
发表时间：
2021
影响因子：
2.8
作者：
Ramakrishnan S;Janssens W;Burgel PR;Contoli M;Franssen FME;Greening NJ;Greulich T;Gyselinck I;Halner A;Huerta A;Morgan RL;Quint JK;Vanfleteren LEGW;Vermeersch K;Watz H;Bafadhel M
通讯作者：
Bafadhel M
DOI：
10.1007/978-1-4939-7113-8_1
发表时间：
2017-01-01
期刊：
FIBROSIS: METHODS AND PROTOCOLS
影响因子：
--
作者：
Rosenbloom, Joel;Macarak, Edward;Jimenez, Sergio A.
通讯作者：
Jimenez, Sergio A.
DOI：
10.1016/j.techfore.2019.07.002
发表时间：
2019-10-01
影响因子：
12
作者：
Belton, Ian;MacDonald, Alice;Hamlin, Iain
通讯作者：
Hamlin, Iain