Interaction between estradiol and prolactin on vasoactive intestinal peptide concentrations in the hypothalamus and in the anterior pituitary of the female rat
Interaction between estradiol and prolactin on vasoactive intestinal peptide concentrations in the hypothalamus and in the anterior pituitary of the female rat
复制标题
雌二醇和催乳素对雌性大鼠下丘脑和垂体前叶血管活性肠肽浓度的相互作用
DOI：
10.1016/0304-3940(82)90312-3
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发表时间：
1982
影响因子：
2.5
通讯作者：
Gabriel Rosselin
中科院分区：
文献类型：
--
作者：
M. Maletti;William Rostène;L. Carr;L. Carr;H. Scherrer;D. Rotten;Claude Kordon;Gabriel Rosselin
为了确定血管活性肠肽（VIP）是否可以通过改变血浆雌二醇和催乳素水平来调节，我们用特异性放射线免疫法测定了高泌乳素血症雌性大鼠脑各结构和垂体中的VIP浓度。在去卵巢大鼠中，单独植入雌二醇（E2）和同时移植E2和垂体诱导实验性高泌乳素血症，与去卵巢大鼠相比，下丘脑前部和中基底部的VIP水平下降，垂体的VIP水平升高。切除卵巢后仅移植垂体的大鼠下丘脑VIP浓度未见改变，而垂体明显升高。这些结果表明，在雌性大鼠中，e2对下丘脑VIP水平的影响可能是通过间接机制产生的，并且这种作用可以通过血浆催乳素水平的升高而增强。
To determine whether vasoactive intestinal peptide (VIP) can be regulated by modification of plasma estradiol and prolactin levels, VIP concentrations in various structures of the rat brain and in the pituitary were measured in hyperprolactinemic female rats by means of a specific radioimmunoassay for the peptide. In ovariectomized rats treated with estradiol (E2) implants alone and with both E2and pituitary grafts to induce an experimental hyperprolactinemia, VIP levels decreased in the anterior and mediobasal hypothalamus and increased in the pituitary as compared to ovariectomized rats. No modification of hypothalamic VIP concentrations was observed in ovariectomized rats with pituitary grafts only, whereas a significant increase was found in the pituitary. These results suggest that, in the female rats, E2exerts an effect on hypothalamic VIP levels, probably through indirect mechanisms, and that this action can be enhanced by elevated plasma prolactin levels.
高催乳素血症可以抵消睾酮引起的视前区多巴胺周转的抑制。
影响因子：
4.1
作者：
Kalra,PS;Simpkins,JW;Kalra,SP
通讯作者：
Kalra,SP