USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor.
USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor.
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DOI：
10.18632/oncotarget.2165
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发表时间：
2014-08-30
期刊：
影响因子：
--
通讯作者：
Burrows JF
中科院分区：
文献类型：
--
作者：
Jaworski J;de la Vega M;Fletcher SJ;McFarlane C;Greene MK;Smyth AW;Van Schaeybroeck S;Johnston JA;Scott CJ;Rappoport JZ;Burrows JF
Previously we have shown that expression of the deubiquitinating enzyme USP17 is required for cell proliferation and motility. More recently we reported that USP17 deubiquitinates RCE1 isoform 2 and thus regulates the processing of ‘CaaX’ motif proteins. Here we now show that USP17 expression is induced by epidermal growth factor and that USP17 expression is required for clathrin mediated endocytosis of epidermal growth factor receptor. In addition, we show that USP17 is required for the endocytosis of transferrin, an archetypal substrate for clathrin mediated endocytosis, and that USP17 depletion impedes plasma membrane recruitment of the machinery required for clathrin mediated endocytosis. Thus, our data reveal that USP17 is necessary for epidermal growth factor receptor and transferrin endocytosis via clathrin coated pits, indicate this is mediated via the regulation of the recruitment of the components of the endocytosis machinery and suggest USP17 may play a general role in receptor endocytosis.
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影响因子：
4.8
作者：
Meijer, Inez M. J.;van Leeuwen, Jeroen E. M.
通讯作者：
van Leeuwen, Jeroen E. M.
影响因子：
4.8
作者：
Bowers, K;Piper, SC;Luzio, JP
通讯作者：
Luzio, JP
影响因子：
4
作者：
Halstead, Jonathan R.;Savaskan, Nicolai E.;Divecha, Nullin
通讯作者：
Divecha, Nullin
DOI：
10.1111/j.1600-0854.2008.00788.x
发表时间：
2008-09
期刊：
Traffic (Copenhagen, Denmark)
影响因子：
--
作者：
Galperin E;Sorkin A
通讯作者：
Sorkin A
影响因子：
--
作者：
Chung BM;Raja SM;Clubb RJ;Tu C;George M;Band V;Band H
通讯作者：
Band H