Current concepts on diagnosis, autoantibodies and therapy in Sjögren's syndrome.
Current concepts on diagnosis, autoantibodies and therapy in Sjögren's syndrome.
复制标题
干燥综合征的诊断、自身抗体和治疗的最新概念。
DOI：
10.1080/030097400447525
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发表时间：
2000
影响因子：
2.1
通讯作者：
Tom P. Gordon
中科院分区：
文献类型：
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作者：
Roland Jonsson;Hans;Tom P. Gordon
干燥综合征是一种慢性自身免疫性风湿性疾病。大多数患者有轻度至中度的主诉，这可能解释了人群研究中发现的患病率与诊所中进行的研究相比存在巨大差异的原因。然而，尽管已经设计了几种分类标准，但对于干燥综合征还没有直接且简单的诊断测试。欧洲和美国的研究小组共同努力提出了一套新的分类标准。据报道，干燥综合征中存在大量自身抗体，在某些情况下，这些抗体与疾病的范围和严重程度相关。针对毒蕈碱 M3 受体的血清自身抗体的发现，不仅有助于了解腺体功能受损的发病机制，而且有助于了解一些患者自主神经功能障碍的相关特征。原发性干燥综合征的治疗仍以对症治疗为主。
Sjögren's syndrome is a chronic autoimmune and rheumatic disorder. Most patients have mild to moderate complaints and this may explain the great discrepancy in prevalence found in population studies compared to studies performed in the clinic. However, there is no straightforward and simple diagnostic test for Sjögren's syndrome, although several classification criteria have been designed. Initiatives have been taken to propose a new set of classification criteria in a joint effort by research groups in Europe and USA. A large number of autoantibodies have been reported in Sjögren's syndrome where, in some cases, the antibodies are correlated with the extent and severity of disease. The finding of serum autoantibodies directed against the muscarinic M3 receptor is an important advance in understanding the pathogenesis of not only the impaired glandular function but also associated features of autonomic dysfunction in some patients. The treatment of primary Sjögren's syndrome is still mainly symptomatic.
干燥综合征患者类风湿因子交叉反应独特型的表达。
DOI：
--
发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fox,RI;Chen,P;Carson,DA;Fong,S
通讯作者：
Fong,S
DOI：
--
发表时间：
1999-06
期刊：
The Journal of rheumatology
影响因子：
--
作者：
P. B. Martens;S. Pillemer;L. Jacobsson;W. O'Fallon;E. Matteson
通讯作者：
P. B. Martens;S. Pillemer;L. Jacobsson;W. O'Fallon;E. Matteson