The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase.
The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase.
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DOI：
10.1371/journal.pone.0029313
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Chammas R
中科院分区：
文献类型：
--
作者：
Melo FH;Butera D;Junqueira Mde S;Hsu DK;da Silva AM;Liu FT;Santos MF;Chammas R
Expression of galectin-3 is associated with sarcoma progression, invasion and metastasis. Here we determined the role of extracellular galectin-3 on migration of sarcoma cells on laminin-111. Cell lines from methylcholanthrene-induced sarcomas from both wild type and galectin-3−/− mice were established. Despite the presence of similar levels of laminin-binding integrins on the cell surface, galectin-3−/− sarcoma cells were more adherent and less migratory than galectin-3+/+ sarcoma cells on laminin-111. When galectin-3 was transiently expressed in galectin-3−/− sarcoma cells, it inhibited cell adhesion and stimulated the migratory response to laminin in a carbohydrate-dependent manner. Extracellular galectin-3 led to the recruitment of SHP-2 phosphatase to focal adhesion plaques, followed by a decrease in the amount of phosphorylated FAK and phospho-paxillin in the lamellipodia of migrating cells. The promigratory activity of extracellular galectin-3 was inhibitable by wortmannin, implicating the activation of a PI-3 kinase dependent pathway in the galectin-3 triggered disruption of adhesion plaques, leading to sarcoma cell migration on laminin-111.
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影响因子：
15.9
作者：
Bornstein, P
通讯作者：
Bornstein, P
影响因子：
3
作者：
Grassadonia, A;Tinari, N;Iacobelli, S
通讯作者：
Iacobelli, S
影响因子：
4.8
作者：
Guo, Hua-Bei;Randolph, Matthew;Pierce, Michael
通讯作者：
Pierce, Michael
DOI：
10.1083/jcb.200709019
发表时间：
2008-03-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Goetz JG;Joshi B;Lajoie P;Strugnell SS;Scudamore T;Kojic LD;Nabi IR
通讯作者：
Nabi IR
影响因子：
8
作者：
Califice, S;Castronovo, V;van den Brûle, F
通讯作者：
van den Brûle, F