Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD.

Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD.
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DOI:
10.1016/j.jaip.2021.09.003
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发表时间:
2021-11
期刊:
The journal of allergy and clinical immunology. In practice
影响因子:
--
通讯作者:
Sharma S
Sharma S
中科院分区:
其他
文献类型:
--
作者:
Althoff MD;Ghincea A;Wood LG;Holguin F;Sharma S

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哮喘是一种复杂的疾病,具有不完全了解的异质表型和内型。肥胖、阻塞性睡眠呼吸暂停和胃食管反流病在哮喘患者中的并发率高于非哮喘患者。虽然这些疾病有共同的危险因素,但有一些数据表明这些合并症具有共同的炎症途径,推动哮喘的发展或恶化哮喘控制。本综述讨论了这些常见合并症的流行病学、病理生理学、管理建议和关键知识差距。
Asthma is a complex disease with heterogenous phenotypes and endotypes that are incompletely understood. Obesity, obstructive sleep apnea, and gastroesophageal reflux disease co-occur in asthmatics at higher rates than non-asthmatics. While these diseases share risk factors, there are some data suggesting these comorbidities have shared inflammatory pathways, drive the development of asthma or worsen asthma control. This review discusses the epidemiology, pathophysiology, management recommendations and key knowledge gaps of these common comorbidities.
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