Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD.
Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD.
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DOI:
10.1016/j.jaip.2021.09.003
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发表时间:
2021-11
期刊:
影响因子:
--
通讯作者:
Sharma S
中科院分区:
文献类型:
--
作者:
Althoff MD;Ghincea A;Wood LG;Holguin F;Sharma S
Asthma is a complex disease with heterogenous phenotypes and endotypes that are incompletely understood. Obesity, obstructive sleep apnea, and gastroesophageal reflux disease co-occur in asthmatics at higher rates than non-asthmatics. While these diseases share risk factors, there are some data suggesting these comorbidities have shared inflammatory pathways, drive the development of asthma or worsen asthma control. This review discusses the epidemiology, pathophysiology, management recommendations and key knowledge gaps of these common comorbidities.
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