Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008.
Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008.
复制标题
1992年至2008年，美国癌症幸存者第二次主要恶性肿瘤的风险。
作者：
Donin N;Filson C;Drakaki A;Tan HJ;Castillo A;Kwan L;Litwin M;Chamie K
在目前的研究中，作者试图描述常见癌症幸存者中第二原发恶性肿瘤的发病率、最常见部位和死亡率。作者从监测、流行病学和最终结果数据中确定了1992年至2008年期间10个最常见癌症部位（前列腺、乳腺、肺、结肠、直肠、膀胱、子宫、肾、黑色素瘤和非霍奇金淋巴瘤）诊断为原发性恶性肿瘤的≥18岁患者。使用双变量和多变量模型探讨与第二原发恶性肿瘤发生率相关的因素，并检查归因于第一和第二原发恶性肿瘤的死亡率。确定了2，116，163例患者的队列，其中170，865例（8.1%）发生了第二原发性恶性肿瘤。膀胱癌的幸存者患第二种癌症的风险最高。在控制年龄、种族、肿瘤分级、疾病分期、婚姻状况、教育水平和收入的多变量模型中，非霍奇金淋巴瘤（男性和女性的风险比分别为2.70和2.88）和膀胱癌（男性和女性的风险比分别为1.88和1.66）的病史预测了发生第二种癌症的最高风险。对于患有2种癌症的患者，13%死于最初的癌症，但超过一半（55%）死于第二种原发性恶性肿瘤。肺癌是12%的2例癌症患者的死亡原因。在12名被诊断患有常见癌症的患者中，有近1人发展为第二种恶性肿瘤，其中最常见的是肺癌。超过一半的2例癌症患者死于继发性恶性肿瘤。目前研究的结果可能会为癌症幸存者的护理策略提供信息。
In the current study, the authors attempted to describe the incidence, most common sites, and mortality of second primary malignancies among survivors of common cancers. The authors identified patients aged ≥18 years who were diagnosed with a primary malignancy from the 10 most common cancer sites (prostate, breast, lung, colon, rectum, bladder, uterus, kidney, melanoma, and non-Hodgkin lymphoma) between 1992 and 2008 from Surveillance, Epidemiology, and End Results data. Factors associated with the incidence of second primary malignancies were explored using bivariable and multivariable models, and mortality attributable to first and second primary malignancies was examined. A cohort of 2,116,163 patients was identified, 170,865 of whom (8.1%) developed a second primary malignancy. Survivors of bladder cancer had the highest risk of developing a second cancer. In a multivariable model controlling for age, race, tumor grade, stage of disease, marital status, educational level, and income, a history of non-Hodgkin lymphoma (hazard ratios of 2.70 and 2.88, respectively, for men and women) and bladder cancer (hazard ratios of 1.88 and 1.66, respectively, for men and women) predicted the highest risk of developing a second cancer. For patients with 2 incident cancers, 13% died of their initial cancer, but greater than one-half (55%) died of their second primary malignancy. Lung cancer was the cause of death in 12% of patients with 2 incident cancers. Nearly 1 in 12 patients diagnosed with a common cancer developed a second malignancy, the most common of which was lung cancer. Greater than one-half of patients with 2 incident cancers died of their secondary malignancy. The findings from the current study may inform care strategies among cancer survivors.
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DOI：
10.1007/s11764-013-0278-6
发表时间：
2013-09
期刊：
Journal of cancer survivorship : research and practice
影响因子：
--
作者：
Corkum M;Hayden JA;Kephart G;Urquhart R;Schlievert C;Porter G
通讯作者：
Porter G
影响因子：
5.8
作者：
Lu, Chang-Hsien;Lee, Kuan-Der;Chen, Min-Chi
通讯作者：
Chen, Min-Chi
影响因子：
39.2
作者：
Moyer, Virginia A.
通讯作者：
Moyer, Virginia A.
DOI：
10.1016/0360-3016(92)90475-w
发表时间：
1992-01-01
影响因子：
7
作者：
HANKS, GE;PETERS, T;OWEN, J
通讯作者：
OWEN, J
影响因子：
51.1
作者：
de Gonzalez, Amy Berrington;Curtis, Rochelle E.;Kry, Stephen F.;Gilbert, Ethel;Lamart, Stephanie;Berg, Christine D.;Stovall, Marilyn;Ron, Elaine
通讯作者：
Ron, Elaine