Screening for new primary cancers in cancer survivors compared to non-cancer controls: a systematic review and meta-analysis.
Screening for new primary cancers in cancer survivors compared to non-cancer controls: a systematic review and meta-analysis.
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DOI：
10.1007/s11764-013-0278-6
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Porter G
中科院分区：
文献类型：
--
作者：
Corkum M;Hayden JA;Kephart G;Urquhart R;Schlievert C;Porter G
本研究的目的是通过进行系统回顾和荟萃分析，综合比较癌症幸存者和非癌症对照者接受癌症筛查的证据。我们检索了PubMed、EMBASE和CINAHL数据库，从开始到2010年4月1日，使用与癌症、生存率和癌症筛查相关的检索词。如果研究报告了癌症幸存者和非癌症对照之间癌症筛查收据的比较，则纳入研究。我们对乳腺癌、宫颈癌、结直肠癌和前列腺癌筛查收据对癌症生存率的影响进行了荟萃分析。我们的检索策略确定了1，778个标题，其中20个符合我们的纳入/排除标准。在我们的荟萃分析中，与非癌症对照组相比，癌症幸存者更有可能接受乳腺癌、宫颈癌、结直肠癌和前列腺癌的筛查（合并优势比，1.27; 95%CI，1.19-1.36）。我们观察到研究之间的显著异质性，其中大部分在亚组和敏感性分析后仍无法解释。重要的背景因素，如筛查程序如何运作，在主要文献中没有报道。许多癌症幸存者（沿着非癌症对照）仍然没有接受癌症筛查。与非癌症对照组相比，癌症幸存者接受更频繁的新原发性乳腺癌、宫颈癌、结直肠癌和前列腺癌筛查。未来的研究应该寻求确定癌症筛查的增加是否与癌症生存期的改善有关。我们的系统性综述和荟萃分析表明，癌症幸存者比非癌症对照组更频繁地接受第二原发性乳腺癌、宫颈癌、结直肠癌和前列腺癌的筛查。由于许多癌症幸存者患第二种原发性癌症的风险增加，未来的研究应该寻求确定癌症幸存者癌症筛查的增加是否会导致癌症生存期间的结果改善。
The goal of this study was to synthesize evidence comparing cancer screening receipt between cancer survivors and non-cancer controls by conducting a systematic review and meta-analysis. We searched PubMed, EMBASE, and CINAHL databases from inception through April 1, 2010 using search terms related to cancer, survivorship, and cancer screening. Studies were included if they reported a comparison of cancer screening receipt between cancer survivors and non-cancer controls. We performed a meta-analysis on the effect of cancer survivorship on breast, cervical, colorectal, and prostate cancer screening receipt. Our search strategy identified 1,778 titles, of which 20 met our inclusion/exclusion criteria. In our meta-analyses, cancer survivors were more likely to be screened for breast, cervical, colorectal, and prostate cancer than non-cancer controls (pooled odds ratio, 1.27; 95 % CI, 1.19–1.36). We observed significant heterogeneity between studies, most of which remained unexplained after subgroup and sensitivity analyses. Important contextual factors, such as how screening programs operate, were not reported in the primary literature. Many cancer survivors (along with non-cancer controls) still did not receive cancer screening. Compared with non-cancer controls, cancer survivors receive more frequent screening for new primary breast, cervical, colorectal, and prostate cancers. Future research should seek to determine whether increased uptake of cancer screening is associated with improved outcomes during cancer survivorship. Our systematic review and meta-analysis demonstrated that cancer survivors received more frequent screening for second primary breast, cervical, colorectal, and prostate cancers than non-cancer controls. As many cancer survivors are at an increased risk of developing a second primary cancer, future research should seek to determine whether this increased uptake of cancer screening in cancer survivors leads to improved outcomes during cancer survivorship.
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