Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: changes in clinical presentation and prognosis.
Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: changes in clinical presentation and prognosis.
复制标题
DOI：
10.1080/10428190903026492
复制
发表时间：
2009-08
影响因子：
2.6
通讯作者：
Slager SL
中科院分区：
文献类型：
--
作者：
Zent CS;Ding W;Reinalda MS;Schwager SM;Hoyer JD;Bowen DA;Jelinek DF;Tschumper RC;Call TG;Shanafelt TD;Kay NE;Slager SL
改善医疗护理可能会改变慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL）并发自身免疫性血细胞减少症（AID血细胞减少症）患者的临床表现和生存率。我们回顾了10年来在一个单一机构就诊的1750例CLL患者中75例（4.3%）被诊断为AID血细胞减少症的临床特征、治疗和结局。与历史报告数据相比，我们的研究显示自身免疫性溶血性贫血的发生率较低（2.3%），免疫性血小板减少症（2.0%）和纯红细胞再生障碍性贫血（0.5%）的发生率相似。AID血细胞减少发生在CLL的所有阶段，对治疗反应良好，不改变总生存率，仅6例（12%）患者死亡。我们认为，更敏感和准确的CLL诊断方法降低了AID血细胞减少症的患病率，改善管理可能会增加这些患者的生存率。
Improved medical care could have altered the clinical presentation and survival of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) complicated by autoimmune cytopenia (AID cytopenia). We reviewed the clinical characteristics, treatment, and outcome of AID cytopenia that was diagnosed in 75 (4.3%) of 1750 CLL patients seen at a single institution over 10 years. Compared to historical reported data, our study shows a lower rate of autoimmune hemolytic anemia (2.3%), and similar rates of immune thrombocytopenia (2.0%) and pure red blood cell aplasia (0.5%). AID cytopenia occurred at all stages of CLL, responded well to treatment, did not alter overall survival, and contributed to death in only 6 (12%) patients. We propose that more sensitive and accurate diagnostic methods for CLL have decreased the perceived prevalence of AID cytopenia and that improvements in management could have increased the survival of these patients.
登录
查看更多内容
影响因子：
20.3
作者：
Dearden, Claire;Wade, Rachel;Catovsky, Daniel
通讯作者：
Catovsky, Daniel
影响因子：
6.5
作者：
Zent, Clive S.;Ding, Wei;Slager, Susan L.
通讯作者：
Slager, Susan L.
影响因子：
20.3
作者：
Byrd, JC;Rai, K;Larson, RA
通讯作者：
Larson, RA
影响因子：
20.3
作者：
RAI, KR;SAWITSKY, A;PASTERNACK, BS
通讯作者：
PASTERNACK, BS
影响因子：
158.5
作者：
Crespo, M;Bosch, F;Montserrat, E
通讯作者：
Montserrat, E