Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review).
Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review).
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DOI：
10.3892/ol.2014.1909
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发表时间：
2014-05
期刊：
影响因子：
2.9
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Tan F;Thiele CJ;Li Z
塌陷反应介质蛋白（CRMPs）最初被确定为信号蛋白3A信号传导和神经元分化的介质。CRMP家族由5个同源胞质蛋白CRMP1-5组成。在肺癌、乳腺癌、结直肠癌、前列腺癌、胰腺癌和神经内分泌肺癌等多种恶性肿瘤中均观察到CRMPs表达水平的改变。本研究的目的是回顾近年来在了解肿瘤中不同水平的CRMP表达与其参与病理功能（如肿瘤转移、疾病进展、亚型分化和临床结局）之间的关系方面取得的进展，以探讨CRMP作为癌症患者诊断和预后的生物标志物的潜在价值。
The collapsin response mediator proteins (CRMPs) were originally identified as mediators of semaphorin 3A signaling and neuronal differentiation. The CRMP family consists of five homologous cytosolic proteins, CRMP1-5. Altered expression levels of CRMPs have been observed in several malignant tumors, including lung, breast, colorectal, prostate, pancreatic and neuroendocrine lung cancer. The aim of the current study was to review the recent progress achieved in understanding the association between the different levels of CRMP expression in tumors and their involvement in pathological functions, such as tumor metastasis, disease progression, subtype differentiation and clinical outcome, to address the potential value of CRMPs as biomarkers for the diagnosis and prognosis of cancer patients.
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