Autophagy and metastasis: another double-edged sword.
Autophagy and metastasis: another double-edged sword.
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DOI：
10.1016/j.ceb.2009.10.008
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发表时间：
2010-04
影响因子：
7.5
通讯作者：
Debnath J
中科院分区：
文献类型：
--
作者：
Kenific CM;Thorburn A;Debnath J
为了发生转移，肿瘤细胞在扩散进入体循环并在远处器官部位定植时，必须适应不利的、有压力的微环境。自噬是一种在细胞应激时上调的受到严格调控的溶酶体自我消化过程，已被证明可抑制原发性肿瘤的形成，但自噬如何影响转移仍然未知。自噬可能通过促进抗肿瘤炎症反应或限制休眠肿瘤细胞扩增为大转移灶来抑制转移。相反，在转移进展过程中，自噬可能通过增强肿瘤细胞对诸如失巢凋亡等环境压力的适应性来促进转移。由于自噬是可调节的，根据肿瘤细胞在整个转移过程中所处的环境需求，它可能具有促进和抑制转移的双重功能。
In order to metastasize, tumor cells must adapt to untoward, stressful microenvironments as they disseminate into the systemic circulation and colonize distant organ sites. Autophagy, a tightly regulated lysosomal self-digestion process that is upregulated during cellular stress, has been demonstrated to suppress primary tumor formation, but how autophagy influences metastasis remains unknown. Autophagy may inhibit metastasis by promoting anti-tumor inflammatory responses or by restricting the expansion of dormant tumor cells into macrometastases. Conversely, self-eating may promote metastasis by enhancing tumor cell fitness in response to environmental stresses, such as anoikis, during metastatic progression. Because autophagy is titratable, it may serve both pro- and anti-metastatic functions depending on the contextual demands placed on tumor cells throughout the metastatic process.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
11.2
作者：
Barkan D;Kleinman H;Simmons JL;Asmussen H;Kamaraju AK;Hoenorhoff MJ;Liu ZY;Costes SV;Cho EH;Lockett S;Khanna C;Chambers AF;Green JE
通讯作者：
Green JE
影响因子：
11.8
作者：
Mailleux, Arnaud A.;Overholtzer, Michael;Brugge, Joan S.
通讯作者：
Brugge, Joan S.
影响因子：
78.5
作者：
Mathew, Robin;Karantza-Wadsworth, Vassiliki;White, Eileen
通讯作者：
White, Eileen
影响因子：
4.8
作者：
Han, Jie;Hou, Wen;Rabinowich, Hannah
通讯作者：
Rabinowich, Hannah