Cardiometabolic factors and breast cancer risk in U.S. black women.
Cardiometabolic factors and breast cancer risk in U.S. black women.
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DOI：
10.1007/s10549-012-2131-4
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发表时间：
2012-08
影响因子：
3.8
通讯作者：
Rosenberg, Lynn
中科院分区：
文献类型：
--
作者：
Bosco, Jaclyn L. F.;Palmer, Julie R.;Boggs, Deborah A.;Hatch, Elizabeth E.;Rosenberg, Lynn
先前的研究表明，代谢综合征可能与乳腺癌风险增加有关，尤其是绝经后妇女，但尚未对美国黑人妇女进行评估。在黑人妇女健康研究中，我们单独研究了腹部肥胖、2型糖尿病、高血压和高胆固醇与乳腺癌发病率的关系。通过Cox回归模型，我们估计了自我报告的腹部肥胖、2型糖尿病、高血压和高胆固醇的基线值和时间依赖值与乳腺癌发病率之间的发生率比（IRR）和95%置信区间（CI）。从1995年到2007年，在516,452人年的随访中（平均10.5年，标准差2.9年），发现了1,228例乳腺癌病例。在调整了年龄、受教育程度、18岁时的体重指数、身体活动和个体心脏代谢因素后，总体而言，个体或组合的心脏代谢因素都与乳腺癌发病率无关；与不存在所有因素相比，组合≥3个因素的多变量IRR为1.04 (95% CI 0.86-1.25)，而具有所有4个因素的多变量IRR为1.17（0.85-1.60）。然而，绝经后妇女的可比irs分别为1.23（0.93-1.62）和1.63（1.12-2.37）。我们的研究结果为绝经后美国黑人妇女的心脏代谢因素与乳腺癌发病率之间的联系提供了一些支持。
Previous studies have suggested that metabolic syndrome may be associated with an increased risk of breast cancer, particularly in postmenopausal women, but U.S. black women have not been assessed. We examined the associations of abdominal obesity, type 2 diabetes, hypertension, and high cholesterol individually and in combination with breast cancer incidence in the Black Women’s Health Study. By means of Cox regression models, we estimated incidence rate ratios (IRR) and 95 % confidence intervals (CI) for the associations of baseline and time-dependent values of self-reported abdominal obesity, type 2 diabetes, hypertension, and high cholesterol with breast cancer incidence. During 516,452 person years of follow-up (mean years = 10.5; standard deviation = 2.9) from 1995 to 2007, 1,228 breast cancer cases were identified. After adjustment for age, education, body mass index at age 18, physical activity, and individual cardiometabolic factors, neither individual nor combinations of cardiometabolic factors were associated with breast cancer incidence overall; the multivariable IRR was 1.04 (95 % CI 0.86–1.25) for the combination of ≥3 factors relative to the absence of all factors, and 1.17 (0.85–1.60) for having all four factors. Among postmenopausal women, however, the comparable IRRs were 1.23 (0.93–1.62) and 1.63 (1.12–2.37), respectively. Our findings provide some support for an association between cardiometabolic factors and breast cancer incidence among postmenopausal U.S. black women.
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DOI：
10.1016/j.numecd.2009.02.006
发表时间：
2010-01
期刊：
Nutrition, metabolism, and cardiovascular diseases : NMCD
影响因子：
--
作者：
Agnoli C;Berrino F;Abagnato CA;Muti P;Panico S;Crosignani P;Krogh V
通讯作者：
Krogh V
DOI：
10.1158/1055-9965.epi-09-0235
发表时间：
2009-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kabat GC;Kim M;Chlebowski RT;Khandekar J;Ko MG;McTiernan A;Neuhouser ML;Parker DR;Shikany JM;Stefanick ML;Thomson CA;Rohan TE
通讯作者：
Rohan TE
影响因子：
--
作者：
Inoue, Manami;Iwasaki, Motoki;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro
DOI：
10.1093/jnci/djh216
发表时间：
2004-08-04
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Furberg, AS;Veierod, MB;Thune, I
通讯作者：
Thune, I
影响因子：
5
作者：
FOLSOM, AR;KAYE, SA;WALLACE, RB
通讯作者：
WALLACE, RB