Metabolic syndrome and postmenopausal breast cancer in the ORDET cohort: a nested case-control study.
Metabolic syndrome and postmenopausal breast cancer in the ORDET cohort: a nested case-control study.
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DOI：
10.1016/j.numecd.2009.02.006
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Krogh V
中科院分区：
文献类型：
--
作者：
Agnoli C;Berrino F;Abagnato CA;Muti P;Panico S;Crosignani P;Krogh V
近几十年来，乳腺癌发病率的增加伴随着代谢综合征频率的增加。一些研究表明，乳腺癌的风险与代谢综合征的组成部分（高血糖和甘油三酯，低HDL-胆固醇，高血压和腹部肥胖）有关，但没有前瞻性研究调查明确定义的代谢综合征的风险。我们在一项对绝经后妇女的ORDET队列进行的巢式病例对照研究中调查了代谢综合征及其组分与乳腺癌风险之间的关系。经过13.5年的中位随访，163名女性患上了乳腺癌; 29.8%的女性患有代谢综合征。每例病例通过发病密度抽样选择4个匹配对照，并通过条件logistic回归估计率比。代谢综合征（即存在三种或三种以上代谢综合征组分）与乳腺癌风险显著相关（率比1.58 [95%置信区间1.07-2.33]），组分数量增加风险显著增加（趋势P 0.004）。在个体代谢综合征组分中，只有低血清HDL-胆固醇和高甘油三酯与风险增加显著相关。这项前瞻性研究表明，代谢综合征是绝经后妇女乳腺癌的一个重要危险因素。虽然血清HDL-胆固醇和甘油三酯与乳腺癌的关联最强，但所有成分都可能通过多种相互作用机制导致风险增加。通过改变生活方式来预防或逆转代谢综合征可能对预防绝经后妇女乳腺癌有效。
The increase in breast cancer incidence over recent decades has been accompanied by an increase in the frequency of metabolic syndrome. Several studies suggest that breast cancer risk is associated with the components of metabolic syndrome (high serum glucose and triglycerides, low HDL-cholesterol, high blood pressure, and abdominal obesity), but no prospective study has investigated risk in relation to the presence of explicitly defined metabolic syndrome. We investigated associations between metabolic syndrome, its components, and breast cancer risk in a nested case-control study on postmenopausal women of the ORDET cohort. After a median follow-up of 13.5 years, 163 women developed breast cancer; metabolic syndrome was present in 29.8%. Four matched controls per case were selected by incidence density sampling, and rate ratios were estimated by conditional logistic regression. Metabolic syndrome (i.e. presence of three or more metabolic syndrome components) was significantly associated with breast cancer risk (rate ratio 1.58 [95% confidence interval 1.07–2.33]), with a significant risk increase for increasing number of components (P for trend 0.004). Among individual metabolic syndrome components, only low serum HDL-cholesterol and high triglycerides were significantly associated with increased risk. This prospective study indicates that metabolic syndrome is an important risk factor for breast cancer in postmenopausal women. Although serum HDL-cholesterol and triglycerides had the strongest association with breast cancer, all components may contribute to increased risk by multiple interacting mechanisms. Prevention or reversal of metabolic syndrome by life-style changes may be effective in preventing breast cancer in postmenopausal women.
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影响因子：
5
作者：
CAULEY, JA;GUTAI, JP;POWELL, JG
通讯作者：
POWELL, JG
DOI：
10.1093/jnci/djh216
发表时间：
2004-08-04
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Furberg, AS;Veierod, MB;Thune, I
通讯作者：
Thune, I
影响因子：
5
作者：
Golden, SH;Ding, J;Dobs, A
通讯作者：
Dobs, A
影响因子：
4.9
作者：
McTernan, PG;Anwar, A;Kumar, S
通讯作者：
Kumar, S
影响因子：
45.3
作者：
Goodwin, PJ;Ennis, M;Hood, N
通讯作者：
Hood, N