The Impact of Consuming Zinc-Biofortified Wheat Flour on Haematological Indices of Zinc and Iron Status in Adolescent Girls in Rural Pakistan: A Cluster-Randomised, Double-Blind, Controlled Effectiveness Trial.
The Impact of Consuming Zinc-Biofortified Wheat Flour on Haematological Indices of Zinc and Iron Status in Adolescent Girls in Rural Pakistan: A Cluster-Randomised, Double-Blind, Controlled Effectiveness Trial.
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作者：
小麦的生物强化可能是改善锌摄入量的可持续策略;然而，需要证据证明其有效性。在巴基斯坦农村进行了一项以家庭为基础的双盲随机分组对照试验（RCT）。主要目的是研究食用锌生物强化小麦粉对10-16岁少女锌状况的影响（n = 517）。家庭收到锌生物强化面粉或对照面粉25周，血液样本和24小时的饮食召回收集矿物质状态和锌摄入量的评估。采用电感耦合等离子体质谱法测定血浆锌、硒和铜浓度，免疫法测定血清铁蛋白、转铁蛋白受体、α 1-酸性糖蛋白和C-反应蛋白。食用锌生物强化面粉导致锌（1.5毫克/天）和铁（1.2毫克/天）的摄入量适度增加。这对PZC没有显著影响（对照组641.6 ± 95.3 µg/L vs.干预组643.8 ± 106.2 µg/L; p = 0.455），但储存铁缺乏率总体降低（SF < 15 µg/L;对照组11.8% vs.干预组1.0%）。食用锌生物强化面粉增加了锌的摄入量（21%），但与PZC的增加无关。建立锌状态的敏感生物标志物是一个持续的优先事项。
Biofortification of wheat is potentially a sustainable strategy to improve zinc intake; however, evidence of its effectiveness is needed. A household-based, double-blind, cluster-randomized controlled trial (RCT) was conducted in rural Pakistan. The primary objective was to examine the effects of consuming zinc-biofortified wheat flour on the zinc status of adolescent girls aged 10–16 years (n = 517). Households received either zinc-biofortified flour or control flour for 25 weeks; blood samples and 24-h dietary recalls were collected for mineral status and zinc intake assessment. Plasma concentrations of zinc (PZC), selenium and copper were measured via inductively coupled plasma mass spectrometry and serum ferritin (SF), transferrin receptor, alpha 1-acid glycoprotein and C-reactive protein by immunoassay. Consumption of the zinc-biofortified flour resulted in a moderate increase in intakes of zinc (1.5 mg/day) and iron (1.2 mg/day). This had no significant effect on PZC (control 641.6 ± 95.3 µg/L vs. intervention 643.8 ± 106.2 µg/L; p = 0.455), however there was an overall reduction in the rate of storage iron deficiency (SF < 15 µg/L; control 11.8% vs. 1.0% intervention). Consumption of zinc-biofortified flour increased zinc intake (21%) but was not associated with an increase in PZC. Establishing a sensitive biomarker of zinc status is an ongoing priority.
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影响因子：
4.2
作者：
Ahmad S;Bailey EH;Arshad M;Ahmed S;Watts MJ;Stewart AG;Young SD
通讯作者：
Young SD
影响因子：
105.7
作者：
Campbell, MK;Elbourne, DR;Altman, DG
通讯作者：
Altman, DG
影响因子：
5.9
作者：
Brazier AKM;Lowe NM;Zaman M;Shahzad B;Ohly H;McArdle HJ;Ullah U;Broadley MR;Bailey EH;Young SD;Tishkovskaya S;Khan MJ
通讯作者：
Khan MJ
影响因子：
4.7
作者：
Ahmed, F;Khan, MR;Fuchs, GJ
通讯作者：
Fuchs, GJ
DOI：
10.1093/ajcn/nqab379
发表时间：
2022-03-04
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Jongstra R;Hossain MM;Galetti V;Hall AG;Holt RR;Cercamondi CI;Rashid SF;Zimmermann MB;Mridha MK;Wegmueller R
通讯作者：
Wegmueller R