Volumetric and anatomical MRI for hypoxic-ischemic encephalopathy: relationship to hypothermia therapy and neurosensory impairments.
Volumetric and anatomical MRI for hypoxic-ischemic encephalopathy: relationship to hypothermia therapy and neurosensory impairments.
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DOI：
10.1038/jp.2008.184
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发表时间：
2009-02
影响因子：
2.9
通讯作者：
Tyson, J. E.
中科院分区：
文献类型：
--
作者：
Parikh, N. A.;Lasky, R. E.;Garza, C. N.;Bonfante-Mejia, E.;Shankaran, S.;Tyson, J. E.
关键词：
将体积MRI结果与低温治疗和神经感觉损伤联系起来。参加本中心NICHD低温随机试验的妊娠≥36周伴有缺氧缺血性脑病的新生儿符合条件。我们确定了低温治疗和常规护理（对照）与绝对和相对脑组织体积之间的关系。此外，我们将脑容量与18至22个月时的死亡或神经感觉损伤联系起来。两个治疗组在随机化前具有可比性。脑组织总体积与治疗分配没有差异。然而，在低温治疗中，皮层下白质的相对体积明显大于对照组婴儿。此外，相对总脑容量与死亡或神经感觉损伤显著相关。皮层灰质和皮层下白质的相对体积也与Bayley Scales精神运动发展指数显著相关。选定的体积MRI结果与低温治疗和神经感觉障碍相关。需要使用MRI脑容量作为次要结果测量的更大规模的研究。
To relate volumetric MRI findings to hypothermia therapy and neurosensory impairments. Newborns ≥ 36 weeks’ gestation with hypoxic-ischemic encephalopathy who participated in the NICHD hypothermia randomized trial at our center were eligible. We determined the relationship between hypothermia treatment and usual care (control) to absolute and relative cerebral tissue volumes. Further, we correlated brain volumes with death or neurosensory impairments at 18 to 22 months. Both treatment groups were comparable before randomization. Total brain tissue volumes did not differ in relation to treatment assignment. However, relative volumes of subcortical white matter were significantly larger in hypothermia-treated than control infants. Furthermore, relative total brain volumes correlated significantly with death or neurosensory impairments. Relative volumes of the cortical gray and subcortical white matter also correlated significantly with Bayley Scales psychomotor development index. Selected volumetric MRI findings correlated with hypothermia therapy and neurosensory impairments. Larger studies utilizing MRI brain volumes as a secondary outcome measure are needed.
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